ArticleBMC plant biology2025
Genome-wide identification, molecular docking and expression analysis of enzymes involved in the primary and secondary metabolic branching points of the selenium metabolic pathway in Cardamine hupingshanensis.
Article in BMC plant biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Selenoproteins: Minute yet vital players governing cellular fate.Genes & diseases · 2026Review
- Computational analysis and expression profiling of the Sulfate Transporter gene family in tomato under selenium and abiotic stress treatment.BMC plant biology · 2026Article
- The mechanism and application of the selenium hyperaccumulator Cardamine hupingshanensis: status and challenges.Annals of botany · 2026Review
- Article
- Genome-wide identification and expression analysis under selenium stress of glutaredoxin system genes in Cardamine hupingshanensis.BMC plant biology · 2026Article
- Genome-Wide Thioredoxin System inBiology · 2025Article
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Authors and funding
12 authors.
Funding
Abstract
backgroundCardamine hupingshanensis is a plant known for its unique selenium tolerance, making it a key model for selenium metabolism research. Adenosine phosphosulfate kinase (APK) and adenosine phosphosulfate reductase (APR) are widely distributed in plants and play a crucial role in selenium metabolism. While genome-wide analyses of the APK and APR families have been conducted across various plant species, a systematic identification and analysis of these gene families in Cardamine hupingshanensis is still lacking.
resultsThere are 7 ChAPK and 5 ChAPR genes identified from the genome of C. hupingshanensis, which can be classified into 4 subfamilies for ChAPK and 3 subfamilies for ChAPR, respectively. All these members share similar conserved motifs and gene structures. Phylogenetic and promoter analyses suggest they are involved in environmental responses, phytohormone regulation, and light signalling. Molecular docking analysis indicated that ChAPK enzymes have a higher affinity for adenosine phosphoselenate (APSe) compared to ChAPR. In 3D interaction force analysis, residues such as His
conclusionsAll members of ChAPK and ChAPR families have a strong affinity for APSe and are regulated by the redox state. However, only three members of ChAPK (ChAPK1-1, ChAPK1-2, and ChAPK4-2) are regulated by the redox state, and these are located in the chloroplast. Furthermore, low concentrations of selenium in the nutrient solution can promote antioxidant activity in the leaves of C. hupingshanensis seedlings, whereas high concentrations of selenium exhibit the opposite effect, as confirmed by the results of oxidative metabolite and antioxidant enzyme assays.
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