Evidence map›Paper›PMID 40405027›Full record

ArticleAIDS and behavior2025

Identifying Syndemic Factors and Their Effect on HIV Sexual Risk Behavior Among Gay, Bisexual and Other Men Who Have Sex with Men in Vancouver, Montreal and Toronto.

Felipe Duailibe, Tian Shen, Wendy Zhang, David Moore, Mark Hull, Justin Barath, Carly Magee, Nathan Lachowsky, Trevor Hart, Joseph Cox and 7 more

Abstract read
In one paragraph

Article in AIDS and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Felipe DuailibeBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada.
Tian ShenBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada.
Wendy ZhangBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada.
David MooreBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada.
Mark HullBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada.
Justin BarathBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada.
Carly MageeBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada.
Nathan LachowskyBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada.
Trevor HartToronto Metropolitan University, Toronto, ON, Canada.
Joseph CoxMcGill University, Montréal, QC, Canada.
Daniel GraceUniversity of Toronto, Toronto, ON, Canada.
Gilles LambertMcGill University, Montréal, QC, Canada.
Shayna Skakoon-SparlingToronto Metropolitan University, Toronto, ON, Canada.
Jody JollimoreCanadian AIDS Treatment Information Exchange, Toronto, ON, Canada.
Milada DvorakovaResearch Institute of the McGill University Health Centre, Montréal, QC, Canada.
Aki GormezanoBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada.
Viviane Dias LimaBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada. vlima@bccfe.ca.ORCID http://orcid.org/0000-0003-4943-091X

Funding

Canadian Foundation for AIDS Research Canadian Foundation for AIDS ResearchCanadian Institutes for Health Research Canadian Institutes for Health ResearchCanadian Institutes for Health Research PJT-156147Canadian Institutes for Health Research TE2-138299Michael Smith Health Research BC 16863;5209Ontario HIV Treatment Network 1051Ontario HIV Treatment Network Ontario HIV Treatment NetworkPublic Health Agency of Canada 4500345082Toronto Metropolitan University Toronto Metropolitan University
6 · The paper itself

Abstract

We set out to identify syndemic factors associated with HIV sexual risk behavior among HIV-negative gay, bisexual and other men who have sex with men (GBM), and examine associations between syndemic factors and HIV sexual risk behaviors using models of co-occurring epidemics. We used baseline data from 1571 sexually active GBM from the Engage Cohort study, recruited using respondent-driven sampling in Montreal, Toronto, and Vancouver. We explored associations between potential syndemic factors and HIV sexual risk behavior, and used oblique component analysis to reduce the number of variables. Path analysis and logistic regression with interaction terms were used to evaluate the association of syndemic factors with HIV sexual risk behavior. In the mediation model, childhood sexual abuse (CSA) was associated with HIV sexual risk behavior (total effect: c = 0.14, 95% CI 0.06-0.21). This effect was mediated by any intimate partner violence (IPV), transactional sex, polysubstance use, and sexual compulsivity. We observed a multiplicative interaction between CSA and transactional sex: GBM with a history of both had 14 times the odds of HIV sexual risk behavior (aOR of 14.0 95% CI 5.6-35.2) compared to those with neither. The appropriate application of a syndemic approach allowed a nuanced assessment of syndemic factor associations with HIV sexual risk behavior. IPV, transactional sex, sexual compulsivity, and polysubstance use mediated the effect of CSA on HIV sexual risk behavior. Additionally, we found a significant multiplicative interaction between CSA and transactional sex.

Indexed as

BisexualityHIV InfectionsHomosexuality, MaleRisk-TakingSexual and Gender MinoritiesSexual BehaviorSyndemicUnsafe SexAdultCanadaCohort StudiesHumansMaleMiddle AgedOntarioQuebecHIV sexual risk behaviorInteractionsMediationMen who have sex with menSyndemics

Identifiers

PMID40405027
PMCPMC12484301

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.