ArticleDiscover oncology2025
Relationship between red cell distribution width and lung cancer: evidence from Mendelian randomization and National Health and Nutrition Examination Survey.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Predictive value of systemic immune-inflammatory markers for lung cancer-associated cerebral infarction: a retrospective cohort study.American journal of cancer research · 2026Article
- Association between red blood cell distribution width to albumin ratio and prostate specific antigen based on NHANES data.American journal of translational research · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundLung cancer remains a primary contributor to cancer-related mortality globally. Red blood cell distribution width (RDW), a straightforward and cost-effective indicator, measures the variability in red blood cell size and is conventionally employed in hematological assessments for anemia differentiation. Nonetheless, limited research has explored the causal link between RDW levels and lung cancer incidence.
methodsInitially, Mendelian randomization (MR) was employed to explore the underlying causal connection between RDW and lung cancer. To ensure the robustness of the MR findings, sensitivity analyses were conducted. Following this, the National Health and Nutrition Examination Survey (NHANES) database was utilized to further substantiate the influence of RDW on the prognosis of lung cancer.
resultsThe MR analysis revealed a significant association between RDW and lung cancer risk in the European population (OR IVW 1.11, 95% CI 1.03-1.20, p = 0.006; OR Weighted-median 1.16, 95% CI 1.03-1.31, p = 0.013; OR MR-Egger 1.14, 95% CI 1.00-1.30, p = 0.059). Furthermore, findings from the NHANES database suggested that lower RDW values are associated with improved prognosis in lung cancer patients (HR 2, 95% CI 1.07-3.74, p < 0.05).
conclusionsOur study provides further evidence for the relationship between RDW levels and lung cancer, highlighting the potential significance of RDW as a biomarker for predicting lung cancer risk and prognosis.
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