Evidence map›Paper›PMID 40404976›Full record

ReviewNature reviews. Microbiology2026

Evolution, spread and impact of highly pathogenic H5 avian influenza A viruses.

Beatriz Bellido-Martín, Willemijn F Rijnink, Matteo Iervolino, Thijs Kuiken, Mathilde Richard, Ron A M Fouchier

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

  1. Counting cases, conserving species: addressing highly pathogenic avian influenza in wildlife.Biological reviews of the Cambridge Philosophical Society · 2026
    Review
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  5. Influenza.Nature reviews. Disease primers · 2026
    Review
  6. Article
  7. Observational
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  9. Review
  10. Article
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  12. Perspective on human diagnostic and national reference laboratory preparedness for zoonotic influenza in Europe.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2026
    Article
  13. Allopatric coevolution: Migratory predators may facilitate mimicry between geographically nonoverlapping species.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Beatriz Bellido-Martín *Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.
Willemijn F Rijnink *Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-3151-3725
Matteo Iervolino *Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.ORCID http://orcid.org/0009-0000-8476-4638
Thijs KuikenDepartment of Viroscience, Erasmus MC, Rotterdam, The Netherlands.
Mathilde RichardDepartment of Viroscience, Erasmus MC, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-0240-9312
Ron A M FouchierDepartment of Viroscience, Erasmus MC, Rotterdam, The Netherlands. r.fouchier@erasmusmc.nl.ORCID http://orcid.org/0000-0001-8095-2869

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since their first detection in 1996, highly pathogenic avian influenza viruses with H5 haemagglutinin of the A/Goose/Guangdong/1/1996 (Gs/Gd) lineage have caused outbreaks in domestic and wild animals associated with mass morbidity and mortality, and economic losses as well as sporadic human infections. These viruses have spread to hosts across the European, Asian, African, and North and South American continents, and most recently Antarctica, representing a major threat to wildlife, domestic animals and humans. Owing to continuous circulation in poultry, Gs/Gd lineage viruses have diversified into numerous distinct genetic and antigenic (sub)clades, and genetic diversity has further increased by extensive reassortment with low pathogenic avian influenza viruses of wild birds. In this Review, we discuss the historical emergence of Gs/Gd lineage viruses and their evolution and geographical spread. An overview of the major determinants of host range and cross-species transmission is provided to summarize phenotypic changes that may signal increased zoonotic or pandemic risks. The recent unusual outbreaks in wild carnivorous mammals and dairy cows is discussed, as well as the changing risk to humans. Countermeasures and mitigation strategies are described from the One Health perspective for future (pre-)pandemic preparedness.

Indexed as

Evolution, MolecularInfluenza A virusInfluenza, HumanInfluenza in BirdsAnimalsAnimals, WildBirdsDisease OutbreaksGenetic VariationHemagglutinin Glycoproteins, Influenza VirusHost SpecificityHumansPoultryZoonosesHemagglutinin Glycoproteins, Influenza Virus

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.