SynthesisEye (London, England)2025
Comparative efficacy and safety of rituximab, tocilizumab, and teprotumumab in Graves' orbitopathy: a systematic review and meta-analysis.
Synthesis in Eye (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Efficacy and safety of tocilizumab in the treatment of Graves' orbitopathy: a systematic review and meta-analysis.BMC endocrine disorders · 2026Pooled it
- Switching from Originator Tocilizumab to Biosimilar in Giant Cell Arteritis: Evaluation of Effectiveness and Safety in a Multicenter Cohort of 38 Patients.Drugs & aging · 2026Observational
- Clinical predictors of tocilizumab response in moderate-to-severe thyroid eye disease: a large single-center retrospective cohort study.Frontiers in endocrinology · 2026Article
- Teprotumumab for Thyroid Eye Disease: Mechanism, Clinical Efficacy, and Current Challenges.Antibodies (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Graves' orbitopathy (GO) affects 25-50% of patients with Graves' disease. It progresses through phases, from active inflammation to fibrosis. Thyrotropin-related antibodies (TRAb) and Insulin-like growth factor (IGF-1) contribute to GO's pathogenesis. Conventional treatments like glucocorticoids are often effective, but refractory cases require alternatives like rituximab (RTX), tocilizumab (TCZ), and teprotumumab (TPM). These monoclonal antibodies show promise but carry significant risks. This review aims to assess their efficacy and safety. We retrieved relevant articles up to July 2024 from five databases. Data were extracted from eligible studies by two independent reviewers, including clinical activity scores 7 and 10 (CAS), proptosis, antibody levels, and diplopia. All analyses were conducted using RevMan v5.4. In this review, we included 77 articles. Of these, 58 provided enough data for analysis. TPM, RTX, and TCZ all significantly reduced CAS-7 scores, with TCZ showing the most significant reduction (3.51 points, 95%CI: -4.25, -2.78), followed by TPM (3.1 points, 95%CI: -3.71, -2.49) and RTX. Similarly, for CAS-10, TCZ led with a 5.12-point reduction, significantly outperforming RTX (P = 0.0006). Proptosis decreased significantly with each drug, with TPM leading (2.95 mm), followed by TCZ (1.99 mm) and RTX (0.79 mm). TRAb Levels: TCZ reduced TRAb levels by 8.29 U/L (95%CI: -10.48, -6.09), significantly more than RTX (P = 0.03). Complications varied, with TPM linked to hyperglycemia and ototoxicity, TCZ to hematologic and metabolic issues, and RTX to infusion-related reactions. In conclusion, TCZ and TPM outperform RTX in treating GO, but TPM has higher complications, and RTX, though safer, shows more treatment failures.
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