Evidence map›Paper›PMID 40404961›Full record

ArticleWorld journal of pediatrics : WJP2025

Antenatal depressive and anxiety symptoms in early pregnancy and offspring allergic diseases during toddlerhood.

Jia-Ying Wu, Yi-Shu Wang, Yan-Hui Hao, Chen-Chi Duan, Yan Xu, Fang-Yue Zhou, Wen Yu, Li Xia, Ting Wu, Xuan-Ping Wang and 5 more

Abstract read
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In one paragraph

Article in World journal of pediatrics : WJP, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jia-Ying WuInternational Peace Maternity and Child Health Hospital, Shanghai Key Laboratory of Embryo Original Disease, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Yi-Shu WangInternational Peace Maternity and Child Health Hospital, Shanghai Key Laboratory of Embryo Original Disease, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Yan-Hui HaoInstitute of Reproduction and Development, Shanghai Key Laboratory of Reproduction and Development, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
Chen-Chi DuanInstitute of Reproduction and Development, Shanghai Key Laboratory of Reproduction and Development, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
Yan XuDepartment of Obstetrics, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Fang-Yue ZhouInstitute of Reproduction and Development, Shanghai Key Laboratory of Reproduction and Development, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
Wen YuInstitute of Reproduction and Development, Shanghai Key Laboratory of Reproduction and Development, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
Li XiaInstitute of Reproduction and Development, Shanghai Key Laboratory of Reproduction and Development, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
Ting WuInternational Peace Maternity and Child Health Hospital, Shanghai Key Laboratory of Embryo Original Disease, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Xuan-Ping WangInternational Peace Maternity and Child Health Hospital, Shanghai Key Laboratory of Embryo Original Disease, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Si-Wei ZhangInstitute of Reproduction and Development, Shanghai Key Laboratory of Reproduction and Development, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
Si-Yue ChenInstitute of Reproduction and Development, Shanghai Key Laboratory of Reproduction and Development, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
Xian XiaDepartment of Obstetrics, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China. xiaxian@fudan.edu.cn.
Yan-Ting WuInstitute of Reproduction and Development, Shanghai Key Laboratory of Reproduction and Development, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China. yanting_wu@163.com.
He-Feng HuangInternational Peace Maternity and Child Health Hospital, Shanghai Key Laboratory of Embryo Original Disease, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. huanghefg@hotmail.com.ORCID 0000-0002-0195-985X

Funding

CAMS Innovation Fund for Medical Sciences 2019-I2M-5-064Clinical Research Plan of Shanghai Shenkang Hospital Development Center SHDC2020CR1008AClinical Research Plan of Shanghai Shenkang Hospital Development Center SHDC2023CRD001Clinical research program of Shanghai Municipal Health Commission 202340222Collaborative Innovation Program of Shanghai Municipal Health Commission 2020CXJQ01Key Discipline Construction Project (2023-2025) of Three-Year Initiative Plan for Strengthening Public Health System Construction in Shanghai GWVI-11.1-35National Key Research and Development Program of China 2022YFC2703500National Natural Science Foundation of China 82088102National Natural Science Foundation of China 8211101588National Natural Science Foundation of China 82171686Natural Science Foundation of Shanghai 20ZR1463100Program of Shanghai Academic Research Leader 20XD1424100Shanghai Clinical Research Center for Gynecological Diseases 22MC1940200Shanghai Urogenital System Diseases Research Center 2022ZZ01012STI2030-Major Projects 2021ZD0200700the specific research fund of The Innovation Platform for Academicians of Hainan Province YSPTZX202311
6 · The paper itself

Abstract

backgroundWhile maternal psychological stress during mid-to-late pregnancy has been linked to offspring allergies, the impact of early pregnancy distress remains unclear. This study investigates the association between maternal depressive and anxiety symptoms in early pregnancy and allergic diseases in offspring.

methodsBased on a birth cohort of 5263 children, antenatal depressive and anxiety symptoms in early pregnancy were assessed via the Patient Health Questionnaire and Generalized Anxiety Disorder Questionnaire, respectively. Allergic outcomes, including asthma, atopic dermatitis (AD), and allergic rhinitis (AR), were evaluated via structured questionnaires. Relative risks (RRs) with 95% confidence intervals (CIs) were estimated via generalized linear models, whereas restricted cubic splines were used to explore linear and non-linear associations between maternal distress and allergic outcomes.

resultsMaternal depressive symptoms in early pregnancy were associated with an increased risk of AD [adjusted RR (95% CI) = 1.15 (1.03-1.29)] and AR [1.52 (1.29-1.79)]. Maternal anxiety symptoms in early pregnancy were associated with increased risks of AD [1.11 (1.02-1.21), mild anxiety] and AR [1.33 (1.04-1.68), moderate to severe anxiety]. Dose‒response analyses revealed graded relationships between distress severity and allergic outcomes. In the joint analysis, comorbid depression and anxiety in early pregnancy were associated with an increased risk of AD [1.15 (1.05-1.26)] and AR [1.42 (1.23-1.63)]. Subgroup analysis revealed a greater risk of asthma for boys born to mothers with mild anxiety [1.95 (1.20-3.15)] but not for girls.

conclusionMaternal distress in early pregnancy is associated with an increased risk of allergic diseases in offspring during toddlerhood.

Indexed as

AnxietyDepressionHypersensitivityPregnancy ComplicationsPrenatal Exposure Delayed EffectsAdultAsthmaChild, PreschoolCohort StudiesFemaleHumansInfantMalePregnancyRhinitis, AllergicAllergic diseaseAntenatal anxietyAntenatal depressionEarly pregnancy

Identifiers

PMID40404961

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.