Evidence map›Paper›PMID 40404946›Full record

SynthesisMolecular neurobiology2025

Microglial Responses to MSC-EVs Treatment in Animal and Cellular Models of Ischemic Stroke: a Systematic Review with Meta-analysis.

Luis Pedro Bernardi, Thomas Hugentobler Schlickmann, Giovanna Carello-Collar, Marco Antonio De Bastiani, Eduardo Rigon Zimmer, Elizandra Braganhol, Francieli Rohden, Diogo Onofre Souza

Erratum issuedAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Luis Pedro BernardiBiological Sciences Graduate Program: Biochemistry, Department of Biochemistry, Institute of Health Basic Sciences, Federal University of Rio Grande Do Sul (UFRGS), Porto Alegre, Brazil. luispedrobernardi2@gmail.com.
Thomas Hugentobler SchlickmannFaculty of Medicine, Institute of Health Basic Sciences, Federal University of Rio Grande Do Sul (UFRGS), Porto Alegre, Brazil.
Giovanna Carello-CollarBiological Sciences Graduate Program: Biochemistry, Department of Biochemistry, Institute of Health Basic Sciences, Federal University of Rio Grande Do Sul (UFRGS), Porto Alegre, Brazil.
Marco Antonio De BastianiDepartment of Biochemistry, Institute of Health Basic Sciences, Federal University of Rio Grande Do Sul (UFRGS), Porto Alegre, Brazil.
Eduardo Rigon ZimmerDepartment of Biochemistry, Institute of Health Basic Sciences, Federal University of Rio Grande Do Sul (UFRGS), Porto Alegre, Brazil.
Elizandra BraganholBiosciences Graduate Program, Federal University of Health Sciences of Porto Alegre, Porto Alegre, Brazil.
Francieli RohdenDepartment of Biochemistry, Institute of Health Basic Sciences, Federal University of Rio Grande Do Sul (UFRGS), Porto Alegre, Brazil.
Diogo Onofre SouzaDepartment of Biochemistry, Institute of Health Basic Sciences, Federal University of Rio Grande Do Sul (UFRGS), Porto Alegre, Brazil. diogo.bioq@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The modulation of microglial reactivity has emerged as a potential target for developing ischemic stroke therapies. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) possess immunomodulatory properties that may influence microglial responses following ischemia. However, individual studies assessing this influence have provided limited results. Therefore, we conducted a systematic review and meta-analysis to investigate whether MSC-EVs treatment alters microglial responses in animal and cellular models of ischemic stroke. In accordance with the PRISMA 2020 statement, we searched PubMed, Web of Science, and EMBASE until January 2025 for studies assessing cellular and molecular parameters of microglial reactivity following MSC-EVs treatment in models of ischemic stroke. We estimated treatment effects using a random-effects meta-analysis of standardized mean differences and estimated heterogeneity via the I

Indexed as

Extracellular VesiclesIschemic StrokeMesenchymal Stem CellsMicrogliaAnimalsDisease Models, AnimalHumansExtracellular vesiclesMicrogliaStem cellsStroke

Identifiers

PMID40404946

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.