ArticleScientific reports2025
mRNA encoding bone morphogenetic protein-2 facilitated peri-implant bone formation of titanium implants placed in rat femurs.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Optimizing rhBMP-2 Therapy for Bone Regeneration: From Safety Concerns to Biomaterial-Guided Delivery Systems.International journal of molecular sciences · 2025Review
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Authors and funding
7 authors.
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Abstract
This study evaluated the effectiveness of N1-methylpseudouridine-modified mRNA encoding bone morphogenetic protein-2 (BMP-2 mRNA-LNP) in promoting bone growth and improving titanium implant integration in rat femur bone defects. Sixteen Sprague-Dawley rats (32 femurs) were used, with titanium wires implanted in the femoral defects. The defects were divided into four groups (n = 8): 5 µg BMP-2 mRNA-LNP, 15 µg BMP-2 mRNA-LNP, recombinant BMP-2 (rhBMP-2), and Dulbecco's phosphate-buffered saline (dPBS). Following euthanasia at 3 and 6 weeks, Micro-Computed Tomography (micro-CT) was performed to assess bone volume, trabecular architecture, and bone-to-implant contact. Push-out mechanical testing determined the maximal loading force for implant dislodgment, while elemental analysis using Energy-Dispersive X-ray Spectroscopy (EDS) and Scanning Electron Microscopy (SEM) assessed mineralization on the titanium surfaces. The 15 µg BMP-2 mRNA-LNP group demonstrated significantly enhanced bone volume, trabecular thickness, and bone-to-implant contact compared to the control group (p < 0.05). Additionally, this group showed higher calcium and phosphorus content, indicating superior mineralization. Concomitantly, the mean maximal loading force (N) increased in the BMP-2 mRNA-LNP group, though this increase was not statistically significant. These results suggest that BMP-2 mRNA-LNP offers a promising approach to enhance peri-implant bone formation and bone regeneration. While the 15 µg group showed slightly greater bone formation, most experimental parameters showed no significant differences compared to the 5 µg group, suggesting the lower dose may offer a more cost-effective approach without compromising efficacy.
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