ArticleCommunications biology2025
Early life stress impairs hippocampal subfield myelination.
Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Postnatal distress, neonatal cerebellar myelination and neurodevelopmental outcomes at 18 months.Molecular psychiatry · 2026Article
- Distinct spatial associations of adversity with hippocampal macro- and microstructure in early adolescence.bioRxiv : the preprint server for biology · 2026Article
- Early-life adversity in rodents: Experimental design is of the essence.Neurobiology of stress · 2026Article
- Targeting enhancing myelin regeneration reverses cognitive deficits in a mouse model of intellectual disability.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Hippocampal morphometry is altered in infants with congenital heart disease.Brain communications · 2026Article
- Oligodendrocyte lineage cells dysfunction in depression: early life stress, adolescent vulnerability and the emerging role of lipid metabolism.Translational psychiatry · 2025Review
- Early life stress impairs hippocampal subfield myelination.Communications biology · 2025Article
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Authors and funding
6 authors.
Funding
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Abstract
The hippocampus is an archicortical structure that is highly sensitive to experience and is made up of individual subfields. These subfields, crucial for learning and memory, rapidly develop and are vulnerable to early stress, yet the mechanisms are unknown. Here, we analyse data from 520 neonates born between 23 and 42 weeks' gestation to assess how early extrauterine exposure-related stress influences subfield maturation. Subfields are segmented automatically by training a U-net model on infant data using HippUnfold, a novel tool for subfield segmentation. Results indicate that subfield volumes are resilient to early stress, while myelination shows greater vulnerability and variation, which may contribute to long-term outcomes. Notably, subfields are not uniformly impacted by stress, with CA1 and CA2 showing the largest effects. Developmental context, including time spent in and ex utero, primarily influences hippocampal subfield myelination.
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