Evidence map›Paper›PMID 40404729›Full record

ArticleScientific reports2025

Associations between urinary glycosaminoglycans and onset of acute respiratory distress syndrome in sepsis patients: a prospective exploratory study.

Ziyuan Shen, Zhengying Li, Hua Zhang, Xiaoyun Wei, Senhao Wei, Feng Zhao, Cui Yang, Zhukai Cong, Zhongnan Yin, Chenchen Ding and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ziyuan Shen *Department of Critical Care Medicine, Peking University Third Hospital, Beijing, 100191, China.
Zhengying Li *School of Chemical and Environmental Engineering, China University of Mining and Technology-Beijing, Beijing, 100083, China.
Hua Zhang *Center of Epidemiology, Peking University Third Hospital, Beijing, 100191, China.
Xiaoyun Wei *Department of Critical Care Medicine, Peking University Third Hospital, Beijing, 100191, China.
Senhao WeiDepartment of Critical Care Medicine, Peking University Third Hospital, Beijing, 100191, China.
Feng ZhaoDepartment of Critical Care Medicine, Peking University Third Hospital, Beijing, 100191, China.
Cui YangDepartment of Critical Care Medicine, Peking University Third Hospital, Beijing, 100191, China.
Zhukai CongDepartment of Critical Care Medicine, Peking University Third Hospital, Beijing, 100191, China.
Zhongnan YinBiobank, Peking University Third Hospital, Beijing, 100191, China.
Chenchen DingSchool of Chemical and Environmental Engineering, China University of Mining and Technology-Beijing, Beijing, 100083, China.
Cai TieSchool of Chemical and Environmental Engineering, China University of Mining and Technology-Beijing, Beijing, 100083, China. tiecai@cumtb.edu.cn.
Xi ZhuDepartment of Critical Care Medicine, Peking University Third Hospital, Beijing, 100191, China. xizhuccm@bjmu.edu.cn.

Funding

Beijing Municipal Natural Science Foundation 7212130Capital Health Research and Development of Special Fund 2020-2-4094Key Clinical Projects of Peking University Third Hospital BYSYZD2023012National Natural Science Foundation of China 82172166Peking University Third Hospital Cohort Study Project BYSYDL2021010
6 · The paper itself

Abstract

The aim of the current study was to explore the association between urinary glycosaminoglycans and the onset of acute respiratory distress syndrome (ARDS) in sepsis patients. We conducted a prospective cohort study of 49 sepsis patients and collected clinical characteristics, urine, and blood samples within 24 h of admission to the Surgical Intensive Care Unit (SICU) of Peking University Third Hospital. Samples from patients who did not develop ARDS were collected from day 1 to day 7 after SICU admission, while samples from patients who developed ARDS were collected from day 1 to the day of onset, forming time-series data. A liquid chromatography-mass spectrometry (LC-MS) system was used to determine urinary dermatan sulfate (DS), chondroitin sulfate (CS), and heparan sulfate (HS) concentrations; enzyme-linked immunosorbent assay (ELISA) and cytometric bead array (CBA) were used to measure plasma inflammatory factors. The endpoint was the onset of ARDS. We used generalized estimating equations to identify associations between urinary glycosaminoglycans and ARDS onset in sepsis patients. Twenty-two of the 49 sepsis patients developed ARDS, and 132 plasma samples and 132 urine samples were obtained. Between the ARDS and non-ARDS groups, sex, pneumonia, Acute Physiology and Chronic Health Evaluation II (APACHE II), Lung Injury Prediction Score (LIPS), and PaO

Indexed as

GlycosaminoglycansRespiratory Distress SyndromeSepsisAdultAgedBiomarkersChondroitin SulfatesFemaleHeparan SulfateHumansMaleMiddle AgedProspective StudiesBiomarkersChondroitin SulfatesGlycosaminoglycansHeparan SulfateAcute respiratory distress syndromeGlycosaminoglycansInflammatory factorsRisk factorsSepsis

Identifiers

PMID40404729
PMCPMC12098999

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.