Evidence map›Paper›PMID 40404728›Full record

ArticleNPJ Parkinson's disease2025

Systematic review of wearables assessing medication effect on motor function and symptoms in Parkinson's disease.

Emma Packer, Héloïse Debelle, Harry G B Bailey, Rana Zia Ur Rehman, Alison J Yarnall, Lynn Rochester, Lisa Alcock, Silvia Del Din

Abstract read
In one paragraph

Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Adaptive Deep Brain Stimulation for Parkinson's Disease: Navigating the Roadblocks to Clinical Implementation.Movement disorders : official journal of the Movement Disorder Society · 2026
    Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Emma PackerTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.ORCID http://orcid.org/0000-0002-0491-3726
Héloïse DebelleTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.
Harry G B BaileyTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.
Rana Zia Ur RehmanTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.ORCID http://orcid.org/0000-0002-4885-7455
Alison J YarnallTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.
Lynn RochesterTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.
Lisa AlcockTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.ORCID http://orcid.org/0000-0002-8364-9803
Silvia Del DinTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom. Silvia.Del-Din@newcastle.ac.uk.

Funding

Wellcome Trust
6 · The paper itself

Abstract

To improve motor function and symptoms, people with Parkinson's (PwP) typically take dopaminergic medication. In PwP, wearable technology (WT) can provide objective insights into medication effect. This review aims to identify and explore literature which uses WT to quantify the effect of medication on motor function and symptoms in PwP (PROSPERO 2022 CRD42022310018). Nine databases were searched between January 2000-October 2024. Downs and Black quality appraisal assessed study quality. PRISMA guidelines were followed. Amongst the seventy-nine included studies, 50 different WTs were placed across 20 locations on the body, and medication effect was monitored on 13 different motor functions/symptoms. There was great heterogeneity amongst protocols, but many studies were performed in controlled environments, exploring short-term medication effects (ON vs OFF). Medication effect varied, improving certain variables, and having no effect on others. Future research should identify gold-standard protocols to explore medication effect in real-world settings, over prolonged periods.Registration and Protocol PROSPERO 2022 CRD42022310018.

Identifiers

PMID40404728
PMCPMC12098882

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.