ArticleScientific reports2025
Training in normobaric hypoxia induces hematological changes that affect iron metabolism and immunity.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Biomarkers predicting the effectiveness of normobaric altitude training.European journal of applied physiology · 2026Article
- Comparison of adaptations to four weeks of continuous hypoxic training between healthy men with lower and higher initial aerobic fitness.Frontiers in physiology · 2026Article
- Low hypoxia tolerance as a determinant of the proinflammatory phenotype: a trained immunity perspective.Frontiers in immunology · 2026Review
- Effects of hypoxia/hyperoxia exposure on immune function - results from a spacecraft-relevant hypobaric chamber study.Frontiers in physiology · 2025Article
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14 authors.
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Abstract
Altitude training is a method among endurance athletes to enhance performance via hypoxia-induced adaptations. However, individual responses vary significantly, with some athletes even showing performance decrements. Iron metabolism and immune function may influence these adaptations, as hypoxia-induced erythropoiesis increases systemic iron demand, potentially affecting immune cells reliant on iron. This study investigated the interplay between hematological, iron, and immunological variables under controlled normobaric hypoxia. 15 highly trained athletes participated in a 21-day live-high-train-low training camp in a normobaric altitude house. Blood samples were collected pre- and post-camp and at four intermediate time points to measure hematological variables, iron metabolism variables, and immunological variables. Pre- and post-performance was assessed via VO
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