Evidence map›Paper›PMID 40404644›Full record

ReviewNPJ biofilms and microbiomes2025

A polymicrobial perspective into the ecological role of Enterococcus faecalis in dental root canal infections.

Ana Parga, Jade Mattu, Georgios N Belibasakis, Kimberly A Kline, Julian G Leprince, Daniel Manoil

Abstract readReview
In one paragraph

Review in NPJ biofilms and microbiomes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Enterococcus faecalis and Endodontic Treatment Failure: A Qualitative Systematic Review of Its Role and Elimination Strategies.Australian endodontic journal : the journal of the Australian Society of Endodontology Inc · 2026
    Pooled it
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  11. Olanzapine affects bone formation via oralFrontiers in cellular and infection microbiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ana PargaDepartment of Microbiology and Parasitology | Aquatic One Health Research Centre - Faculty of Biology | Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
Jade MattuDMD student | University Clinics of Dental Medicine | Faculty of Medicine | University of Geneva, Geneva, Switzerland.
Georgios N BelibasakisDivision of Oral Health and Periodontology | Department of Dental Medicine | Karolinska Institutet | Huddinge, Stockholm, Sweden.
Kimberly A KlineDepartment of Microbiology and Molecular Medicine | Faculty of Medicine | University of Geneva, Geneva, Switzerland.
Julian G LeprinceDivision of cariology and endodontology | University Clinics of Dental Medicine | Faculty of Medicine | University of Geneva, Geneva, Switzerland.
Daniel ManoilDivision of Oral Health and Periodontology | Department of Dental Medicine | Karolinska Institutet | Huddinge, Stockholm, Sweden. Daniel.Manoil@ki.se.

Funding

Karolinska Institutet Strategic Funds Dnr. 4-823/2019KI/SLL Styrgruppen för Odontologisk Forskning (SOF) FoUI-978687Regional Government of Galicia, Spain ED6481B-2023/117
6 · The paper itself

Abstract

Enterococcus faecalis, a non-oral nosocomial pathogen, intriguingly ranks among the most frequently retrieved species from polymicrobial infections of dental root canals. This review integrates findings from the latest omics approaches, alongside emerging evidence of E. faecalis interactions within oral polymicrobial communities, to refine our understanding of its role in these infections. Herein, E. faecalis emerges as an ecologically invasive species and a catalyst of the pathogenicity of entire communities.

Indexed as

CoinfectionDental Pulp CavityEnterococcus faecalisGram-Positive Bacterial InfectionsBiofilmsHumans

Identifiers

PMID40404644
PMCPMC12098920

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.