Evidence map›Paper›PMID 40404636›Full record

ArticleNature communications2025

NNMT/1-MNA protects against hepatic ischemia-reperfusion injury through the AKT/FOXO1/ANGPT2/JNK axis.

Bing Yin, Baolin Qian, Hongjun Yu, Shanjia Ke, Zihao Li, Yongliang Hua, Shounan Lu, Chaoqun Wang, Mengxin Li, Sixun Guo and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Bing Yin *Department of Minimally Invasive Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Baolin Qian *Department of Minimally Invasive Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Hongjun Yu *Department of Minimally Invasive Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Shanjia Ke *Department of Minimally Invasive Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Zihao LiDepartment of Minimally Invasive Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Yongliang HuaKey Laboratory of Hepatosplenic Surgery, Ministry of Education, Harbin, China.
Shounan LuDepartment of Minimally Invasive Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Chaoqun WangDepartment of Minimally Invasive Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Mengxin LiState Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
Sixun GuoDepartment of Pharmacy, The First affiliated Hospital of Harbin Medical University, Harbin, China.
Zhongyu LiDepartment of Minimally Invasive Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Yongzhi ZhouDepartment of Minimally Invasive Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Zhanzhi MengDepartment of Minimally Invasive Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Xinglong LiDepartment of Minimally Invasive Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Yanan XuKey Laboratory of Hepatosplenic Surgery, Ministry of Education, Harbin, China.ORCID http://orcid.org/0000-0003-3582-8863
Zhigang FengKey Laboratory of Hepatosplenic Surgery, Ministry of Education, Harbin, China.
Miaoyu BaiDepartment of Minimally Invasive Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Yao FuDepartment of Ultrasound, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Wei TangInternational Health Care Center, National Center for Global Health and Medicine, Tokyo, Japan.
Shangyu HongDepartment of Minimally Invasive Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China. shangyu_hong@fudan.edu.cn.ORCID http://orcid.org/0000-0001-6144-5618
Yong MaDepartment of Minimally Invasive Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China. mayong@ems.hrbmu.edu.cn.ORCID http://orcid.org/0000-0002-6508-508X

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82370643
6 · The paper itself

Abstract

Hepatic ischemia‒reperfusion injury (HIRI) occurs during liver surgery, contributing to postoperative complications such as liver failure, prolonged hospital stays, and increased morbidity and mortality rates. Yet, the mechanism underlying HIRI remains unclear. Nicotinamide N-methyltransferase (NNMT) facilitates the conversion of nicotinamide into N

Indexed as

Angiopoietin-2LiverNicotinamide N-MethyltransferaseReperfusion InjuryAnimalsApoptosisDisease Models, AnimalForkhead Box Protein O1HepatocytesHumansMaleMAP Kinase Signaling SystemMiceMice, Inbred C57BLNiacinamideProto-Oncogene Proteins c-aktAngiopoietin-2Forkhead Box Protein O1Foxo1 protein, mouseN(1)-methylnicotinamideNiacinamideNicotinamide N-MethyltransferaseProto-Oncogene Proteins c-akt

Identifiers

PMID40404636
PMCPMC12098763

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.