Evidence map›Paper›PMID 40404548›Full record

ArticleTrends in parasitology2025

Elevating uric acid as an antimalarial target.

Ian Drobish, Hans Ackerman

Abstract read
In one paragraph

Article in Trends in parasitology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ian DrobishPhysiology Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA; Critical Care Medicine Department, NIH Clinical Center, Bethesda, MD, USA; Division of Infectious Diseases, Children's National Hospital, Washington, DC, USA.
Hans AckermanPhysiology Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA. Electronic address: hans.ackerman@nih.gov.

Funding

Nitric Oxide and Endothelial Function in Patients with MalariaZIAAI001150 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI ACKERMAN, HANS · 2011 to 2025
$19.4M
Intramural NIH HHS ZIA AI001150
6 · The paper itself

Abstract

Malaria causes hundreds of thousands of deaths each year in children, and many survivors are left with lasting neurological injury. While we have effective parasite-killing drugs, we need treatments that target disease mechanisms to improve outcomes. Bond et al. recently reported uric acid as a potential target for anti-disease therapy.

Indexed as

AntimalarialsMalariaUric AcidAnimalsHumansAntimalarialsUric AcidhyperuricemiamalariaPlasmodiumuric acidxanthine oxidase, brain

Identifiers

PMID40404548
PMCPMC12226212

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.