Evidence map›Paper›PMID 40404475›Full record

ArticleZhongguo fei ai za zhi = Chinese journal of lung cancer2025

[Analysis of Risk Factors for Meningeal Metastasis in Patients 
with Lung Adenocarcinoma Following Non-surgical Interventions].

Yi Yue, Yuqing Ren, Jianlong Lin, Chunya Lu, Nan Jiang, Yanping Su, Jing Li, Yibo Wang, Sihui Wang, Junkai Fu and 2 more

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yi YueThe First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.
Yuqing RenThe First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.
Jianlong LinThe First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.
Chunya LuThe First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.
Nan JiangThe First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.
Yanping SuThe First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.
Jing LiThe First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.
Yibo WangThe First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.
Sihui WangThe First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.
Junkai FuThe First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.
Mengrui KongThe First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.
Guojun ZhangThe First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMeningeal metastasis (MM) is a form of malignant metastasis where tumor cells spread from the primary site to the pia mater, dura mater, arachnoid, subarachnoid space, and other cerebrospinal fluid compartments. Lung cancer is one of the most common malignant tumor types with MM. MM not only signifies that the lung cancer has progressed to an advanced stage but also leads to a range of severe clinical symptoms due to meningeal involvement. Currently, the risk factors associated with the development of MM are not fully elucidated. The aim of this study was to investigate the risk factors for MM in patients with lung adenocarcinoma (LUAD) who underwent non-surgical interventions, in order to identify LUAD patients at high risk for MM.

methodsThis retrospective study analyzed the clinical data of patients diagnosed with LUAD at the First Affiliated Hospital of Zhengzhou University from January 2020 to July 2024. Missing data were imputed using multiple imputation methods, and risk factors were identified through LASSO, univariate, and multivariate Logistic regression analyses.

resultsA total of 170 patients with LUAD were included in this study and divided into two groups: 87 patients with MM and 83 patients without MM. Univariate and multivariate Logistic regression analyses revealed that younger age at diagnosis (P=0.004), presence of the epidermal growth factor receptor (EGFR) L858R gene mutation (P=0.008), and concurrent liver metastasis at baseline (P=0.004) were independent risk factors for developing MM in LUAD patients who did not undergo surgical intervention. Conversely, higher baseline globulin levels (P=0.039) and the presence of the anaplastic lymphoma kinase (ALK) gene mutation (P=0.040) were associated with a reduced risk of MM development.

conclusionsAge at diagnosis, EGFR L858R mutation status, ALK gene mutation status, concurrent liver metastasis, globulin levels at baseline were significantly associated with the risk of developing MM in patients with LUAD patients who did not undergo surgical intervention. For patients diagnosed at a younger age, carrying the EGFR L858R mutation, or presenting with baseline liver metastasis, early implementation of tertiary prevention strategies for MM is crucial. Regular monitoring of MM status should be conducted in these high-risk groups.

Indexed as

Adenocarcinoma of LungLung NeoplasmsMeningeal NeoplasmsAdultAgedFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsEGFR L858R mutationLiver metastasesLung neoplasmsMeningeal metastasisRisk factors

Identifiers

PMID40404475
PMCPMC12096092

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