ArticlePsychiatry investigation2025
Network Structure of Depression and Anxiety Symptoms in Older Asian Patients With Depressive Disorders: Findings From REAP-AD3.
Article in Psychiatry investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Is Richard Baxter's Melancholia Still Relevant Today?: Comparative Network Structures of Depressive Symptoms in Asian Individuals With Guilt-Rich and Guilt-Free Depression.Psychiatry investigation · 2026Article
- Comparative Network Structures of Hikikomori (Social Withdrawal) Symptoms in Korean and Japanese Psychiatric Patients Prescribed Antidepressants: Findings From the Research on Asian Psychotropic Patterns for Antidepressants, Phase 3.Journal of Korean medical science · 2026Article
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19 authors.
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Abstract
objectiveThe clinical presentation of depressive disorders might be influenced by age, and its diagnosis and treatment can be affected by ageism-related bias. A network analysis can reveal symptom patterns unrecognized by the reductionistic approach. Therefore, this study explores the network structure of depression and anxiety symptoms in older Asian patients with depressive disorders and examines age-related differences in the context of ageism.
methodsWe used data from the Research on Asian Psychotropic Prescription Patterns for Antidepressants, Phase 3 study and included 2,785 psychiatric patients from 11 Asian countries. Depression and anxiety symptoms were assessed using the Patient Health Questionnaire-9 and Generalized Anxiety Disorder-7. Network analyses were conducted to identify symptom interconnections and centrality among older (>65 years), middle-aged (35-64 years), and young (18-34 years) adult groups. The network structures were also compared using a network comparison test.
resultsDepressed mood was the most central symptom across all age groups. Network comparisons revealed no significant structural differences among the three age groups, despite several variations in terms of global strength. The network structure of the older group was characterized by strong interconnections between somatic symptoms (insomnia-energy) and core depressive symptoms (little interest or pleasure-feelings of hopelessness).
conclusionThis study reveals that the network structures of depression and anxiety symptoms have relatively consistent interconnections across age groups, despite subtle age-based differences. Specifically, older adults tend to present anxiety and depression symptoms as physical complaints. These findings challenge ageist stereotypes and advocate for inclusive, age-neutral approaches to treatment.
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