Evidence map›Paper›PMID 40404357›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025

Inhibition of Rho-Associated Kinases ROCK1 and ROCK2 as a Therapeutic Strategy to Reactivate the Repressed

Minggang Fang, Shahid Banday, Sara K Deibler, Tessa M Simone, Madison Coleman, Emerald O'Connor, Rui Li, Lihua Julie Zhu, Michael R Green

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Minggang FangDepartments of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts 01605 minggang.fang@umassmed.edu.
Shahid BandayDepartments of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts 01605.
Sara K DeiblerDepartments of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts 01605.
Tessa M SimoneDepartments of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts 01605.
Madison ColemanDepartments of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts 01605.
Emerald O'ConnorDepartments of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts 01605.
Rui LiDepartments of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts 01605.
Lihua Julie ZhuDepartments of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts 01605.
Michael R GreenDepartments of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts 01605.

Funding

Transcriptional Upregulation of the Epigenetically Repressed FXN Gene as a Therapeutic Approach for Friedreich AtaxiaR01NS114052 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KELLIHER, MICHELLE ALICE · 2019 to 2023
$1.8M
NINDS NIH HHS R01 NS114052
6 · The paper itself

Abstract

Friedreich ataxia (FA) is an autosomal recessive disease characterized by progressive damage to the nervous system and severe cardiac abnormalities. The disease is caused by a GAA•TTC triplet repeat expansion in the first intron of the

Indexed as

Friedreich AtaxiaIron-Binding Proteinsrho-Associated Kinases1-(5-Isoquinolinesulfonyl)-2-MethylpiperazineAnimalsCells, CulturedFemaleFrataxinHumansInduced Pluripotent Stem CellsMaleMiceMice, Transgenic1-(5-Isoquinolinesulfonyl)-2-MethylpiperazineFrataxinIron-Binding Proteinsrho-Associated KinasesROCK1 protein, humanRock1 protein, mouseROCK2 protein, humanRock2 protein, mousefrataxinFriedreich ataxiamitochondrial functionneurodegenerationreactivation of FXNROCK kinases

Identifiers

PMID40404357
PMCPMC12199543

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.