ArticleBMJ paediatrics open2025
Delayed admission temperature normalisation in preterm infants <32 weeks: impact on mortality and neonatal morbidities.
Article in BMJ paediatrics open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Review
- Development and internal validation of machine learning-based models for predicting admission hypothermia in preterm infants: a retrospective cohort study.Frontiers in medicine · 2026Article
- Influence of oropharyngeal therapy with mother's own milk on the microbiome and metabolome of very preterm infants: a pilot study.Frontiers in nutrition · 2025Article
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Authors and funding
13 authors.
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Abstract
objectiveTo evaluate the impact of delayed temperature normalisation on neonatal outcomes, including mortality and major morbidities, in preterm infants born at <32 weeks' gestation.
designRetrospective cohort study.
settingNeonatal Intensive Care Unit at King Abdulaziz Medical City, Riyadh, Saudi Arabia. PATIENTS: Preterm infants born at <32 weeks' gestation between January 2022 and December 2024.
main outcome measuresInfants were categorised into three groups based on temperature normalisation: normothermia at admission, early recovery (<2 hours) and late recovery (>2 hours). Primary outcomes included mortality before discharge, major neonatal morbidities (intraventricular haemorrhage (IVH), necrotising enterocolitis (NEC), bronchopulmonary dysplasia (BPD) and culture-positive sepsis) and duration of mechanical ventilation and hospital stay.
resultsAmong 578 preterm infants, 75% achieved normothermia at admission, 16% recovered within 2 hours and 9% required >2 hours. Mortality was significantly higher in the late recovery group (42%) versus normothermia (7%) and early recovery (11%) (p<0.001). Late recovery was also associated with higher rates of major IVH (27% vs 5% normothermia, 11% early recovery, p<0.001), surgical NEC (10% vs 2% normothermia, 7% early recovery, p=0.001) and BPD (44% vs 16% normothermia, 42% early recovery, p<0.001). The need for mechanical ventilation was highest in the late recovery group (87%) (p<0.001). Kaplan-Meier analysis demonstrated prolonged ventilation and hospital stay (p<0.001).
conclusionsDelayed temperature recovery beyond 2 hours is associated with higher mortality and neonatal morbidities. These findings highlight the importance of early thermal stabilisation to improve outcomes in preterm infants.
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