Evidence map›Paper›PMID 40403946›Full record

ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2026

Symptoms of Constipation: Relationship Between Questionnaires and Diaries and Impact on Quality of Life.

Gad Mehanna Al Snih, Kent R Bailey, Nicholas R Oblizajek, Adil E Bharucha

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Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Gad Mehanna Al SnihDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Kent R BaileyDivision of Biomedical Statistics and Informatics, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, Minnesota.
Nicholas R OblizajekDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Adil E BharuchaDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota. Electronic address: bharucha.adil@mayo.edu.

Funding

Pathophysiology of Anorectal DisordersR01DK078924 · NIDDK · MAYO CLINIC ROCHESTER · PI BHARUCHA, ADIL E. · 2008 to 2023
$5.0M
NIDDK NIH HHS R01 DK078924
6 · The paper itself

Abstract

BACKGROUND &

aimsWidely used to identify constipation in clinical trials and epidemiologic studies, bowel questionnaires have not been adequately validated vs the gold standard approach, diaries. Constipation is associated with poor quality-of-life (QoL). However, the contribution of individual symptoms to QoL is unknown.

methodsBowel symptoms (questionnaires and 2-week bowel diaries), somatic symptom scores (range, 0-4), and bowel symptom-related QoL were evaluated in healthy women and women with constipation in the community and clinic.

resultsThe bowel variables were significantly correlated and not significantly different between the first and second weeks of the diary. Agreement between bowel symptoms assessed with questionnaires and diaries was significant (P < .001) but varied among symptoms. Of 73 participants who reported 0 to 2 stools/week on questionnaires, 63 (86%) recorded more frequent stools in a diary. Among participants with frequent (≥25% of the time) hard stools, straining, and incomplete evacuation on a questionnaire, respectively 32%, 49%, and 23% recorded these symptoms less frequently in a diary. Only 116 of 222 participants (52%) satisfied constipation criteria by questionnaires and diaries; the remainder satisfied either questionnaire or diary criteria. Stool form, excessive straining, incomplete evacuation, and somatic symptoms were independently associated with poor QoL. Each unit increase in the somatic symptom score was associated with an increased odds of poor QoL (odds ratio, 5.31; 95% confidence interval, 4.54-6.08).

conclusionsDisparities exist between bowel symptoms recorded with questionnaires and diaries. Bowel diaries characterize constipation symptoms in a refined manner; only 52% of participants satisfied constipation symptom criteria on both instruments. Somatic symptoms overshadow the contribution of bowel symptoms to QoL.

Indexed as

ConstipationDiaries as TopicQuality of LifeAdultAgedFemaleHumansMiddle AgedSurveys and QuestionnairesYoung AdultAbdominal PainFunctional ConstipationIBSIrritable Bowel Syndrome

Identifiers

PMID40403946
PMCPMC12354092

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.