Evidence map›Paper›PMID 40403780›Full record

ArticleJournal of pain and symptom management2025

End-of-Life Symptoms in Persons Dying With Advanced Dementia in the Community Setting: Findings From IN-PEACE.

Kurt Kroenke, Sujuan Gao, Susan E Hickman, Alexia M Torke, Nina M Johnson, Amy Pemberton, Andrea Vrobel, Minmin Pan, Laura R Holtz, Greg A Sachs

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pain and symptom management, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kurt KroenkeDivision of General Internal Medicine and Geriatrics (K.K., A.M.T., G.A.S.), Indiana University School of Medicine, Indianapolis, Indiana, USA; Center for Health Services Research (K.K.), Regenstrief Institute, Inc, Indianapolis, Indiana, USA; Department of Biostatistics and Health Data Sciences (K.K., S.G., M.P.), Indiana University School of Medicine, Indianapolis, Indiana, USA. Electronic address: kkroenke@regenstrief.org.
Sujuan GaoDepartment of Biostatistics and Health Data Sciences (K.K., S.G., M.P.), Indiana University School of Medicine, Indianapolis, Indiana, USA.
Susan E HickmanCommunity and Health Systems (S.E.H.), Indiana University School of Nursing, Indianapolis, Indiana, USA; Indiana University Center for Aging Research (S.E.H., A.M.T., N.M.J., L.R.H., G.A.S.), Regenstrief Institute, Inc, Indianapolis, Indiana, USA.
Alexia M TorkeDivision of General Internal Medicine and Geriatrics (K.K., A.M.T., G.A.S.), Indiana University School of Medicine, Indianapolis, Indiana, USA; Indiana University Center for Aging Research (S.E.H., A.M.T., N.M.J., L.R.H., G.A.S.), Regenstrief Institute, Inc, Indianapolis, Indiana, USA.
Nina M JohnsonIndiana University Center for Aging Research (S.E.H., A.M.T., N.M.J., L.R.H., G.A.S.), Regenstrief Institute, Inc, Indianapolis, Indiana, USA.
Amy PembertonEskenazi Health (A.P., A.V., G.A.S.), Indianapolis, Indiana, USA.
Andrea VrobelEskenazi Health (A.P., A.V., G.A.S.), Indianapolis, Indiana, USA.
Minmin PanDepartment of Biostatistics and Health Data Sciences (K.K., S.G., M.P.), Indiana University School of Medicine, Indianapolis, Indiana, USA.
Laura R HoltzIndiana University Center for Aging Research (S.E.H., A.M.T., N.M.J., L.R.H., G.A.S.), Regenstrief Institute, Inc, Indianapolis, Indiana, USA.
Greg A SachsDivision of General Internal Medicine and Geriatrics (K.K., A.M.T., G.A.S.), Indiana University School of Medicine, Indianapolis, Indiana, USA; Indiana University Center for Aging Research (S.E.H., A.M.T., N.M.J., L.R.H., G.A.S.), Regenstrief Institute, Inc, Indianapolis, Indiana, USA; Indiana University Health Physicians (G.A.S.), Indianapolis, Indiana, USA; Eskenazi Health (A.P., A.V., G.A.S.), Indianapolis, Indiana, USA.

Funding

Indiana Palliative Excellence in Alzheimer Care Efforts-RCTR01AG057733 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI SACHS, GREG A · 2018 to 2022
$3.7M
Understanding the needs and experiences of surrogate decision makers caring for SGM individuals with Alzheimer's Disease and Related Dementias.K24AG053794 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI TORKE, ALEXIA MARY · 2016 to 2025
$1.8M
NIA NIH HHS K24 AG053794NIA NIH HHS R01 AG057733
6 · The paper itself

Abstract

contextThe symptom burden in persons dying with advanced dementia outside long-term care facilities has not been well studied.

objectivesTo determine the symptom burden in persons dying with advanced dementia in the community setting.

methodsThe sample consisted of patient-caregiver dyads enrolled in the 24-month IN-PEACE trial of home-based care management for advanced dementia. Postmortem interviews were administered to caregivers of persons with advanced dementia who had recently died. The primary outcome was the Comfort Assessment in Dying-End of Life in Dementia (CAD-EOLD) scale. A secondary symptom measure was the Symptom Management in End of Life Dementia (SM-EOLD). Results were analyzed and compared to previous studies using the CAD-EOLD.

resultsOf the 83 persons with dementia who died during 24 months of follow-up, postmortem caregiver interviews were completed in 80 cases of which 79 completed the CAD-EOLD. Patients' mean age was 83.1; 68% were women, 57% white, and 37% African American. Most patients (62%) died at home and only 32% died in a hospital or nursing home. Hospice enrollment occurred in 75% of participants. Symptom management as reflected in CAD-EOLD scores was comparable to previous studies of persons with dementia dying in nursing homes. Compared to baseline SM-EOLD scores, end-of-life symptom scores were 4 points better. Intervention and control group outcomes were similar.

conclusionsSome community-dwelling persons with advanced dementia can die at home with symptom management comparable to that received in nursing homes.

Indexed as

DementiaTerminal CareAgedAged, 80 and overCaregiversFemaleHome Care ServicesHumansMalePalliative CareCAD-EOLDcaregivercommunity-baseddeathDementiadyingpalliative carepsychometricssymptoms

Identifiers

PMID40403780
PMCPMC13102258

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.