Evidence map›Paper›PMID 40403717›Full record

ArticleStructure (London, England : 1993)2025

Chloride binding does not influence prestin motor speed at very high frequencies in the mouse outer hair cell.

Jun-Ping Bai, Chenou Zhang, Iman Bahader, Nicola Strenzke, Vijay Renigunta, Dominik Oliver, Dhasakumar Navaratnam, Oliver Beckstein, Joseph Santos-Sacchi

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Structure (London, England : 1993), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Structural Mechanism of Prestin-Membrane Mechanotransduction.bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Jun-Ping BaiNeurology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA.
Chenou ZhangCenter for Biological Physics and Department of Physics, Arizona State University, Tempe, AZ 85287-1504, USA.
Iman BahaderAuditory Systems Physiology Group, Institute for Auditory Neuroscience and Collaborative Research Center 889 "Cellular Mechanisms of Sensory Processing", University Medical Center Göttingen, 37075 Göttingen, Germany.
Nicola StrenzkeAuditory Systems Physiology Group, Institute for Auditory Neuroscience and Collaborative Research Center 889 "Cellular Mechanisms of Sensory Processing", University Medical Center Göttingen, 37075 Göttingen, Germany.
Vijay ReniguntaInstitute for Physiology and Pathophysiology, Section of Neurophysiology, Philipps University Marburg, Deutschhausstr. 2, 35037 Marburg, Germany.
Dominik OliverInstitute for Physiology and Pathophysiology, Section of Neurophysiology, Philipps University Marburg, Deutschhausstr. 2, 35037 Marburg, Germany.
Dhasakumar NavaratnamSurgery (Otolaryngology), Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA; Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA; Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA.
Oliver BecksteinCenter for Biological Physics and Department of Physics, Arizona State University, Tempe, AZ 85287-1504, USA.
Joseph Santos-SacchiSurgery (Otolaryngology), Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA; Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA; Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA. Electronic address: joseph.santos-sacchi@yale.edu.

Funding

Membrane properties of the OHC systemR01DC016318 · NIDCD · YALE UNIVERSITY · PI DHASAKUMAR S NAVARATNAM, JOSEPH R SANTOS-SACCHI · 2017 to 2026
$6.7M
Structural correlates of prestin activity.R01DC008130 · NIDCD · YALE UNIVERSITY · PI NAVARATNAM, DHASAKUMAR S, SANTOS-SACCHI, JOSEPH R · 2007 to 2021
$6.1M
Breakthrough Molecular Dynamics Research via an Anton2 SupercomputerR01GM116961 · NIGMS · CARNEGIE-MELLON UNIVERSITY · PI BLOOD, PHILIP D. · 2016 to 2023
$3.0M
Structural correlates of prestin activityR56DC021057 · NIDCD · YALE UNIVERSITY · PI NAVARATNAM, DHASAKUMAR S, SANTOS-SACCHI, JOSEPH R · 2023 to 2023
$712k
NIDCD NIH HHS R01 DC008130NIDCD NIH HHS R01 DC016318NIDCD NIH HHS R56 DC021057NIGMS NIH HHS R01 GM116961
6 · The paper itself

Abstract

Prestin (SLC26A5) promotes mechanical feedback via outer hair cells (OHC) within the organ of Corti, governed by voltage-dependent kinetics of its charge movements; namely, nonlinear-capacitance (NLC). We study NLC frequency response in mouse OHC membrane patches. The characteristic frequency cut-off (F

Indexed as

ChloridesHair Cells, Auditory, OuterSulfate TransportersAnimalsBinding SitesMiceMolecular Dynamics SimulationMolecular Motor ProteinsProtein BindingChloridesMolecular Motor ProteinsPres protein, mouseSulfate Transporterscochlea amplificationdisplacement currentsmacro-patchmolecular dynamicsnonlinear capacitanceprestinvoltage-clamp

Identifiers

PMID40403717
PMCPMC12335374

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.