Evidence map›Paper›PMID 40403151›Full record

ArticleJournal of medicinal chemistry2025

Exploring Long Arm Amide-Linked Side Chains in the Design of Antifungal Azole Inhibitors of Sterol 14α-Demethylase (CYP51).

Marwa Alsulaimany, Mikhail V Keniya, Rehab S Alanazi, Yasmeen N Ruma, Carwyn S Hughes, Arwyn T Jones, Joel D A Tyndall, Josie E Parker, Brian C Monk, Claire Simons

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Frontiers in microbiology · 2026
    Article
  3. Decoding resistance inFrontiers in cellular and infection microbiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marwa AlsulaimanySchool of Pharmacy and Pharmaceutical Sciences, Cardiff University, King Edward VII Avenue, Cardiff CF10 3NB, U.K.
Mikhail V KeniyaFaculty of Dentistry, Sir John Walsh Research Institute, University of Otago, Dunedin 9016, New Zealand.
Rehab S AlanaziSchool of Pharmacy and Pharmaceutical Sciences, Cardiff University, King Edward VII Avenue, Cardiff CF10 3NB, U.K.
Yasmeen N RumaFaculty of Dentistry, Sir John Walsh Research Institute, University of Otago, Dunedin 9016, New Zealand.
Carwyn S HughesSchool of Pharmacy and Pharmaceutical Sciences, Cardiff University, King Edward VII Avenue, Cardiff CF10 3NB, U.K.
Arwyn T JonesSchool of Pharmacy and Pharmaceutical Sciences, Cardiff University, King Edward VII Avenue, Cardiff CF10 3NB, U.K.
Joel D A TyndallSchool of Pharmacy, University of Otago, Dunedin 9054, New Zealand.ORCID 0000-0003-0783-1635
Josie E ParkerSchool of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, U.K.
Brian C MonkFaculty of Dentistry, Sir John Walsh Research Institute, University of Otago, Dunedin 9016, New Zealand.
Claire SimonsSchool of Pharmacy and Pharmaceutical Sciences, Cardiff University, King Edward VII Avenue, Cardiff CF10 3NB, U.K.ORCID 0000-0002-9487-1100

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rise in fungal drug resistance has exacerbated the treatment of invasive fungal infections, most commonly caused by

Indexed as

14-alpha Demethylase InhibitorsAmidesAntifungal AgentsAzolesDrug DesignSterol 14-DemethylaseCandidaCryptococcusCrystallography, X-RayMicrobial Sensitivity TestsSaccharomyces cerevisiaeStructure-Activity Relationship14-alpha Demethylase InhibitorsAmidesAntifungal AgentsAzolesSterol 14-Demethylase

Identifiers

PMID40403151
PMCPMC12169614

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.