Evidence map›Paper›PMID 40403128›Full record

ArticleScience (New York, N.Y.)2025

Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense.

Rocky M Barilla, Clara Berard, Linyu Sun, Sumiti Sandhu, Sarah Zaghouani, Krishna S Iyer, Gizem Altun, Chien-Wen Su, Jacques Deguine, Vasundhara Singh and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Intestinal muscularis in health and disease.Communications biology · 2026
    Review
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  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Rocky M BarillaGene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-8062-7246
Clara BerardGene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Linyu SunGene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Sumiti SandhuGene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Sarah ZaghouaniDivision of Medical Sciences, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-4467-6542
Krishna S IyerGene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0009-0004-0414-3540
Gizem AltunGene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0009-0008-8771-7552
Chien-Wen SuMucosal Immunology and Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.ORCID 0000-0002-5457-9295
Jacques DeguineBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-9218-3040
Vasundhara SinghBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Yu HouLiangzhu Laboratory, Zhejiang University, Hangzhou, China.ORCID 0000-0001-7875-7087
Kanupriya KusumakarGene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Michael L RutlinDepartment of Pediatrics, Boston Children´s Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0009-0003-3657-1008
Meenakshi RaoDepartment of Pediatrics, Boston Children´s Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-8194-9204
Habib ZaghouaniUniversity of Missouri School of Medicine, Columbia, MO, USA.
Hai Ning ShiMucosal Immunology and Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Ramnik J XavierGene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-5630-5167
Vijay K KuchrooGene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-7177-2110

Funding

Systematic dissection of gut cellular circuits [at single cell resolution]RC2DK114784 · NIDDK · BROAD INSTITUTE, INC. · PI ASHENBERG, ORR, GRAHAM, DANIEL BARTHOLOMEW · 2017 to 2021
$9.0M
Role of a novel risk loci HAVCR2 of late-onset Alzheimer's disease in the regulation of microglial response in neurodegenerationR01AG080992 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI Oleg Butovsky, VIJAY K. KUCHROO · 2023 to 2026
$3.3M
Neuroimmune interactions regulate development of allergic inflammationR01AI139536 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI KUCHROO, VIJAY K. · 2018 to 2022
$2.9M
Isoform- and Sex-Specific Functions of CGRP in Gastrointestinal MotilityR01DK135707 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI Meenakshi Rao · 2023 to 2026
$2.6M
Neuroimmune interactions regulate development of allergic inflammationR37AI139536 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI VIJAY K. KUCHROO · 2024 to 2026
$1.8M
Training Program in Immunological Tolerance and AutoimmunityT32AI118692 · NIAID · HARVARD MEDICAL SCHOOL · PI PILLAI, SHIV SUBRAMANIAM · 2015 to 2019
$948k
NIAID NIH HHS R01 AI139536NIAID NIH HHS R37 AI139536NIAID NIH HHS T32 AI118692NIA NIH HHS R01 AG080992NIDDK NIH HHS R01 DK135707NIDDK NIH HHS RC2 DK114784
6 · The paper itself

Abstract

Enteric nervous system (ENS)-derived neuropeptides modulate immune cell function, yet our understanding of how inflammatory cues directly influence enteric neuron responses during infection is considerably lacking. Here, we characterized a primary enteric sensory neuron (PSN) subset producing the neuropeptides neuromedin U (NMU) and calcitonin gene-related peptide β (CGRPβ) and coexpressing receptors for the type 2 cytokines interleukin-4 (IL-4) and IL-13. Type 2 cytokines amplified NMU and CGRPβ expression in PSNs both in vitro and in vivo, and this was abrogated by PSN-specific

Indexed as

Calcitonin Gene-Related PeptideEnteric Nervous SystemNematospiroides dubiusNeuropeptidesSensory Receptor CellsStrongylida InfectionsAnimalsInterleukin-13Interleukin-4MiceMice, Inbred C57BLNeuroimmunomodulationCalcitonin Gene-Related PeptideInterleukin-13Interleukin-4neuromedin UNeuropeptides

Identifiers

PMID40403128
PMCPMC12632183

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.