ArticlePloS one2025
Effects of dietary lysine, methionine, and tryptophan on regulating GH-IGF system and modulation of inflammatory and immune response in Pangasius bocourti.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study assessed the effects of methionine, lysine, and tryptophan on the growth performance, amino acid composition, and immune-related gene expression of basa catfish (Pangasius bocourti). Fish (n = 260; initial weight = 10.00 ± 1.00 g) were fed eight isonitrogenous (30%) diets, each containing different combinations of tryptophan (Trp), methionine (Met), and lysine (Lys) (A0: no amino acids, A1: Trp, A2: Lys, A3: Met, A4: Trp + Met, A5: Lys + Trp, A6: Met + Lys, A7: Lys + Trp + Met, 6 g/kg each) for 10 weeks. The experiment consisted of eight treatments, each with three replicates (n = 15/replicate). After the 10-week feeding trial, the fish were intraperitoneally injected with 0.2 mL of Streptococcus iniae for a 14-day bacterial challenge. Following the feeding trial and bacterial challenge, growth parameters, insulin-like growth factor-I, haematological profile, blood biochemistry, interleukin-6, and interleukin-10 revealed that amino acid supplementation significantly improved both growth and immune response in all treatments except A0. Significant differences were observed in crude protein and amino acid profiles across treatments. Interleukin-10 levels were significantly elevated in all treatments except in the positive control (+ve A0). Compared to the positive control, interleukin-6 levels were significantly reduced (P < 0.05) in all treatments. Superoxide dismutase and catalase activity increased in response to the bacterial challenge, while malondialdehyde levels gradually decreased. The A7 diet (Lys + Trp + Met: 6 g/kg) yielded the most favourable results, enhancing the immune response, which may further support the commercial production of Pangasius bocourti.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.