SynthesisFuture cardiology2025
Efficacy and safety of radiofrequency ablation for hypertrophic obstructive cardiomyopathy: a meta-analysis.
Synthesis in Future cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
12 authors.
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Abstract
backgroundHypertrophic obstructive cardiomyopathy (HOCM) is a genetic heart disease leading to obstructive hypertrophy. Radiofrequency ablation (RFA) is a minimally invasive alternative to traditional treatments. This review evaluates RFA's effectiveness and safety for HOCM.
methodsA systematic review and meta-analysis were performed on studies from PubMed, Cochrane, and clinicaltrials.gov up to August 2024. Studies comparing RFA outcomes before and after the procedure were included. Data were analyzed through Revman software, using random-effects models. The funnel plots and Egger test were used for publication bias. Subgroup analysis and sensitivity analysis were also performed.
resultsThis meta-analysis included 16 cohort studies and 2 case series, encompassing 727 patients with ages ranging from 10.4 to 62 years. The studies were conducted in various countries, including China, the USA, Germany, the UK, India, and Brazil. The analysis revealed significant improvements following radiofrequency ablation (RFA): the LVOT gradient at rest was reduced by MD -58.2 (CI: -71.2 to -56.93,
conclusionRFA effectively reduces both LVOT gradients at rest and provoked, improves NYHA functional class, and decreases septal size in HOCM patients.
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