Evidence map›Paper›PMID 40402851›Full record

ReviewJournal of applied microbiology2025

Skin-associated commensal microorganisms and their metabolites.

Rayssa D Lima, Kiana Hajiarbabi, Bren Den Ng, Ankur Sood, Rosana B R Ferreira

Abstract readReview
In one paragraph

Review in Journal of applied microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Skin and gut microbiome in atopic dermatitis: Mechanisms and therapeutic opportunities.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Skin Microbiome in Health and Disease: Mechanisms and Emerging Therapeutic Strategies.Clinical, cosmetic and investigational dermatology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rayssa D LimaDepartment of Molecules Biosciences, The University of Kansas, 1200 Sunnyside Ave, 4023 Haworth Hall, Lawrence, KS 66045, United States.
Kiana HajiarbabiDepartment of Molecules Biosciences, The University of Kansas, 1200 Sunnyside Ave, 4023 Haworth Hall, Lawrence, KS 66045, United States.
Bren Den NgDepartment of Molecules Biosciences, The University of Kansas, 1200 Sunnyside Ave, 4023 Haworth Hall, Lawrence, KS 66045, United States.
Ankur SoodDepartment of Molecules Biosciences, The University of Kansas, 1200 Sunnyside Ave, 4023 Haworth Hall, Lawrence, KS 66045, United States.
Rosana B R FerreiraDepartment of Molecules Biosciences, The University of Kansas, 1200 Sunnyside Ave, 4023 Haworth Hall, Lawrence, KS 66045, United States.ORCID 0000-0002-7162-0026

Funding

Synthetic Chemical Biology CoreP20GM113117 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI OROZCO, ROBIN C. · 2016 to 2025
$23.9M
CAPES 001FAPERJ E-26/010.001280/2016FAPERJ E-26/010.002155/2019FAPERJ E-26/210.209/2018FAPERJ E-26/210.505/2019FAPERJ E-26/211.554/2019FAPERJ SEI-260003/001213/2020NIGMS NIH HHS P20 GM113117NIH HHS P20GM113117University of Kansas
6 · The paper itself

Abstract

The skin microbiome is an essential component on our skin and is critical for the maintenance of skin health. It consists of a diverse ecosystem of bacteria, fungi, and viruses. Different body sites in humans exhibit vastly different levels of sebum, temperature, and pH, therefore the microbes that colonize these areas have adapted to create a niche for colonization. Healthy microbial diversity is important in the normal function of the skin, and imbalances in microbial diversity in the skin microbiome have been found to correlate with several skin diseases, such as atopic dermatitis, acne vulgaris, psoriasis, and chronic wound infections. These microorganisms, especially commensal bacteria, produce various metabolites such as short-chain fatty acids, antimicrobial peptides, siderophores, and tryptophan-derived metabolites. These metabolites can interact with and aid the host in processes, such as wound healing and colonization resistance. Metabolites produced by skin commensals have promising therapeutical potential for drug-resistant bacterial infections in place of conventional antibiotics to combat widespread antibiotic resistance. In this review, we will discuss the composition of the skin microbiota and the different classes of metabolites produced by its members, as well as how changes in the skin microbiome impact certain disease conditions.

Indexed as

BacteriaMicrobiotaSkinAntimicrobial PeptidesFatty Acids, VolatileHumansSiderophoresSkin DiseasesSymbiosisAntimicrobial PeptidesFatty Acids, VolatileSiderophoresantimicrobial peptidesCutibacteriummicrobial metabolitesshort chain fatty acidssiderophoresskin microbiotaStaphylococcus

Identifiers

PMID40402851
PMCPMC12097490

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.