Evidence map›Paper›PMID 40402842›Full record

ArticleAmerican journal of physiology. Renal physiology2025

Renal G protein-coupled estrogen receptor 1 regulates the epithelial sodium channel promoting natriuresis to a greater extent in females.

Victoria L Nasci, Jean C Bopassa, Elena Mironova, Megan Rhoads, Ravneet Singh, Dennis P Buehler, David M Pollock, Oleh M Pochynyuk, James D Stockand, Eman Y Gohar

Abstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. GPER1 activation regulates renal purinergic P2YAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2026
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Victoria L NasciDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.ORCID 0000-0002-1891-8974
Jean C BopassaDepartment of Cellular and Integrative Physiology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States.
Elena MironovaGreehey Children's Cancer Research Institute, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States.
Megan RhoadsDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.ORCID 0000-0001-7494-9815
Ravneet SinghDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
Dennis P BuehlerDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
David M PollockDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.ORCID 0000-0002-0233-2362
Oleh M PochynyukDepartment of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, United States.ORCID 0000-0002-5397-6897
James D StockandDepartment of Cellular and Integrative Physiology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States.ORCID 0000-0002-3817-4319
Eman Y GoharDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.ORCID 0000-0003-0988-6445

Funding

University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
PATHOBIOLOGY OF OCCLUSIVE VASCULAR DISEASET32HL007446 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Jean Chrisostome Bopassa · 1985 to 2026
$8.9M
VANDERBILT NEPHROLOGY TRAINING PROGRAMT32DK007569 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARRIS, RAYMOND C., IKIZLER, TALAT ALP · 1988 to 2024
$5.8M
UAB-UCSD O'Brien Center for Acute Kidney Injury ResearchU54DK137307 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI PAUL W. SANDERS · 2023 to 2026
$4.4M
Significance of Epac signaling in renal Na+handling and hypertensionR01DK136462 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI XIAODONG CHENG, Oleh Pochynyuk · 2024 to 2026
$2.0M
Degradation of Mitochondrial Inner Membrane Protein Disrupts the Structural Interaction between Mitofilin and Cyclophilin D and Determines the Extent of Ischemia/reperfusion injuryR01HL138093 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BOPASSA, JEAN CHRISOSTOME · 2017 to 2021
$1.9M
Unraveling the Impact of Estrogen Signaling on Postmenopausal HypertensionR01HL171122 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eman Gohar · 2024 to 2026
$1.8M
Physiology of ClC-K2/b Cl- channel in the collecting ductR01DK117865 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI POCHYNYUK, OLEH · 2019 to 2023
$1.7M
Sex Differences in Renal Sodium HandlingR00DK119413 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GOHAR, EMAN · 2021 to 2023
$740k
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL171122HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) R00DK119413NHLBI NIH HHS R01 HL138093NHLBI NIH HHS R01 HL171122NHLBI NIH HHS T32 HL007446NIDDK NIH HHS P30 DK079626NIDDK NIH HHS R00 DK119413NIDDK NIH HHS R01 DK117865NIDDK NIH HHS R01 DK136462NIDDK NIH HHS T32 DK007569NIDDK NIH HHS U54 DK137307
6 · The paper itself

Abstract

Hypertension prevalence is lower in women than in men. Enhanced renal sodium (Na

Indexed as

Epithelial Sodium ChannelsKidneyNatriuresisReceptors, G-Protein-CoupledSodiumAnimalsAquaporin 2Endothelin-1FemaleMaleMiceMice, Inbred C57BLMice, KnockoutRatsRats, Sprague-DawleyReceptors, EstrogenAquaporin 2Endothelin-1Epithelial Sodium ChannelsGPER1 protein, mouseGper1 protein, ratReceptors, EstrogenReceptors, G-Protein-CoupledSodiumENaCGPER1hypertensionnatriuresissodium homeostasis

Identifiers

PMID40402842
PMCPMC12208778

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.