Evidence map›Paper›PMID 40402504›Full record

ArticleInhalation toxicology2025

TMEM175 activity in BK-deficient macrophages maintains lysosomal function and mediates silica-induced inflammatory response in macrophages.

Rebekah L Kendall, Britten Postma, Andrij Holian

Abstract read
In one paragraph

Article in Inhalation toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Rebekah L KendallCenter for Environmental Health Sciences, University of Montana, Missoula, Montana, USA.ORCID 0000-0001-5357-7717
Britten PostmaCenter for Environmental Health Sciences, University of Montana, Missoula, Montana, USA.
Andrij HolianCenter for Environmental Health Sciences, University of Montana, Missoula, Montana, USA.

Funding

Lysosomal BK channel regulates cSiO2-induced macrophage inflammationR21ES033511 · NIEHS · UNIVERSITY OF MONTANA · PI HOLIAN, ANDRIJ · 2022 to 2023
$407k
BK potassium channel activity in cSiO2-induced lysosome membrane permeability and inflammationF31ES033562 · NIEHS · UNIVERSITY OF MONTANA · PI KENDALL, REBEKAH · 2021 to 2022
$77k
NIEHS NIH HHS F31 ES033562NIEHS NIH HHS R21 ES033511
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

InflammationLarge-Conductance Calcium-Activated Potassium ChannelsLysosomesMacrophagesSilicon DioxideAnimalsCells, CulturedCholesterolHydrogen-Ion ConcentrationInterleukin-1betaMiceMice, Inbred C57BLMice, KnockoutCholesterolInterleukin-1betaLarge-Conductance Calcium-Activated Potassium ChannelsSilicon Dioxideinflammationion channelsLMPlysosomeMacrophagesilicaTMEM175

Identifiers

PMID40402504
PMCPMC12303735

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.