ArticleJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2025
The relationship between systemic immune-inflammation index and recurrence after cryoballoon ablation for paroxysmal atrial fibrillation.
Article in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- Retrospective evaluation of the relationship between catheter ablation and systemic immune-inflammation index in cardiac arrhythmias.BMC cardiovascular disorders · 2026Article
- C-Reactive Protein-to-Albumin Ratio (CAR) and Left Atrial Diameter Predicts New-Onset Atrial Fibrillation in Chronic Coronary Syndrome: A Retrospective Cohort Study.Journal of clinical medicine · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe effectiveness of lesion formation during cryoballoon ablation (CBA) may be influenced by the extent of acute local inflammation induced during the ablation process. This study aims to evaluate the predictive value of inflammatory markers following CBA.
methodsA total of 102 consecutive patients with paroxysmal atrial fibrillation (AF) who underwent CBA (51.9% male; mean age 56.7 ± 11.5 years) were prospectively included in the study. Blood samples for Systemic Immune-Inflammation Index (SII), C-reactive protein (CRP), lymphocyte counts (LC) were collected from all participants prior to, and within 24 h post-procedure. SII was calculated as platelet count × neutrophil count / lymphocyte count. 12-lead electrocardiograms, clinical evaluations, medical history reviews, and 24-hour Holter monitoring were performed at one, three-, and six-months post-ablation. Recurrences of AF occurring beyond the initial 30-day blanking period were documented and analyzed.
resultsOver a mean follow-up period of 12.3 ± 5.1 months, AF recurrence was observed in 30 (29.4%) patients. SII, CRP, LC, and left atrial end-systolic diameter (LAD), were associated with AF recurrence. Multivariable Cox regression analysis identified post-ablation SII levels as the sole independent predictor of AF recurrence (hazard ratio [HR]: 0.139; 95% confidence interval [CI]: 0.052-0.369; p < 0.001). Receiver operating characteristic (ROC) curve analysis determined an SII cut-off value of 900 for predicting AF recurrence, yielding a sensitivity of 80.0% and specificity of 63.9%. The area under the curve (AUC) was 0.72 (p < 0.001).
conclusionLower post-ablation levels of SII predict AF recurrence following CBA.
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Registered trials
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