Evidence map›Paper›PMID 40402353›Full record

ReviewDiscover oncology2025

Treatment strategies and prognostic insights for lacrimal gland adenoid cystic carcinoma: a review.

Xinyun Wang, Huiling Ma, Ying Chen, Menghui Zhang, Sisi Liu, Huiyan Li, Xiawei Wang, Hongguang Cui

Abstract readReview
In one paragraph

Review in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xinyun Wang *Department of Ophthalmology, The Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu, China. 1314003@zju.edu.cn.
Huiling Ma *Department of Ophthalmology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Ying ChenDepartment of Ophthalmology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Menghui ZhangDepartment of Ophthalmology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Sisi LiuDepartment of Ophthalmology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Huiyan LiDepartment of Ophthalmology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Xiawei WangDepartment of Ophthalmology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Hongguang CuiDepartment of Ophthalmology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China. 1189002@zju.edu.cn.

Funding

the Basic Public Welfare Research Project of Zhejiang Province LGF22H120002
6 · The paper itself

Abstract

Adenoid cystic carcinoma (ACC) is the most common type of malignant tumor in lacrimal gland cancer. The primary treatment approach involves eye-preserving surgery combined with adjuvant radiotherapy, which has proven effective in maintaining visual function and achieving favorable local control with minimal toxicity. However, the 5-year survival rate for ACC of the lacrimal gland remains below 60%. Recently, novel adjuvant therapies, including neoadjuvant intra-arterial chemotherapy, proton radiotherapy, and neutron radiotherapy, have significantly improved survival outcomes. Despite these advances, the rarity of lacrimal gland adenoid cystic carcinoma (LGACC) limits comprehensive studies on long-term survival and the potential for late toxicity, underscoring the need for further research. Additionally, recent findings on pathogenic mechanisms and proteomic abnormalities in LGACC offer a foundation for developing targeted therapies, paving the way for more personalized treatments. This article reviews contemporary treatment strategies and prognostic insights for LGACC, focusing on recent advancements and their implications for patient survival.

Indexed as

Adenoid cystic carcinomaChemotherapyLacrimal glandMolecular targeted therapyRadiotherapySurgery

Identifiers

PMID40402353
PMCPMC12098222

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.