Evidence map›Paper›PMID 40402330›Full record

ReviewImmunologic research2025

tRNA-derived fragments: biomarkers and therapeutic targets in autoimmune diseases.

Akanksha Kaimwal, Muhammed Hadish, Anil Kumar, Ajay Kumar, Anjana Munshi

Abstract readReview
PubMed Publisher
In one paragraph

Review in Immunologic research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Akanksha Kaimwal *Department of Human Genetics and Molecular Medicine, Central University of Punjab, Bathinda, 151401, India.
Muhammed Hadish *Department of Human Genetics and Molecular Medicine, Central University of Punjab, Bathinda, 151401, India.
Anil KumarDepartment of Human Genetics and Molecular Medicine, Central University of Punjab, Bathinda, 151401, India.
Ajay KumarDepartment of Human Genetics and Molecular Medicine, Central University of Punjab, Bathinda, 151401, India.
Anjana MunshiDepartment of Human Genetics and Molecular Medicine, Central University of Punjab, Bathinda, 151401, India. anjana.munshi@cup.edu.in.

Funding

Department of Biotechnology, Ministry of Science and Technology, India Sanction No-BT/PR45460/MED/12/952/2022
6 · The paper itself

Abstract

TRNA-derived fragments (tRFs) are tiny non-coding RNAs that control gene expression and immunological responses. Initially, the tRFs were thought to be only a byproduct of Transfer RNA (tRNA) degradation. Recent studies highlighted their role in autoimmune diseases like type 1 diabetes (T1D), inflammatory bowel disease (IBD), rheumatoid arthritis (RA), sjögren's syndrome (SS) and systemic lupus erythematosus (SLE). The tRFs can influence the gene expression that are potentially involved in autoimmune diseases. The tRFs can alter immune cell function and influence the pathways that lead to autoimmune diseases. This review examines how tRFs impact immune system regulation, such as interactions with messenger RNAs (mRNA), inhibition of apoptosis, and immune cell development. Dysregulation of this leads to the progression or severity of autoimmune diseases. In addition, the potential of tRFs as biomarkers for autoimmune diseases and their targets of novel therapeutic interventions. However, this area is still in its infancy and needs more research to understand the role of a wide range of tRFs in autoimmune diseases.

Indexed as

Autoimmune DiseasesRNA, TransferAnimalsBiomarkersGene Expression RegulationHumansBiomarkersRNA, TransferAutoimmune diseaseGene regulationImmune responseTransfer RNAsTRNA derived fragmentsTRNA-derived stress-induced RNAs

Identifiers

PMID40402330

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.