ArticleSleep & breathing = Schlaf & Atmung2025
Cardiovascular risks in non-dipper OSA patients: insights from ABPM, echocardiography, and Holter monitoring.
Article in Sleep & breathing = Schlaf & Atmung, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Epigenetic Silencing of Carotid Body TRPM7 Attenuates Hypertension in Obese Mice.bioRxiv : the preprint server for biology · 2026Article
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6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA high prevalence of non-dipping diastolic blood pressure (DBP) patterns has been observed in Obstructive Sleep Apnea (OSA), suggesting that diminished circadian blood pressure variability may significantly contribute to hypertensive end-organ damage.
objectivesThis study aimed to evaluate cardiovascular complications in non-dipper OSA patients using a combination of 24-hour Ambulatory Blood Pressure Monitoring (ABPM), Holter electrocardiography, and transthoracic echocardiography (TTE).
methodsThis cross-sectional study assessed 64 adult non-dipper OSA patients. The patients, with an average age of 46.5 years, underwent clinical assessments via sphygmomanometer, resting electrocardiogram (ECG), TTE, 24-hour ABPM, and 24-hour Holter ECG. The average age of the patients was 46.5 years, with 50% exhibiting grade 2 obesity. OSA severity was classified as follows: 42.2% moderate; 32.8% severe; and 25% mild. A positive correlation was identified between OSA severity and body mass index (BMI), diabetes, and hypertension. ABPM revealed masked hypertension in 45% of participants. TTE showed that severe OSA was linked to regional wall motion abnormalities, ischemic changes, and increased interventricular septal thickness. Elevated pulmonary artery systolic pressure is predominantly observed in patients with severe OSA. Holter monitoring detected intermittent atrial fibrillation in 15.6% and infrequent extrasystoles in 31.2%. The multivariate logistic regression analysis identified BMI, age, male gender, and the presence of hypertension and diabetes mellitus as significant risk factors for severe OSA. Higher BMI, age, male gender, and these comorbidities increased the likelihood of severe OSA, with odds ratios of 1.22, 1.03, 2.80, and 1.85, respectively.
conclusionsThe 24-hour ABPM is an effective tool for detecting masked hypertension in non-dipper OSA patients. Additionally, the severity is directly associated with an increased risk of cardiovascular disease (CVD). Regular cardiovascular assessments are recommended for patients with OSA to mitigate potential complications.
trial registrationZUIRB#9417/2042022 Registered 20 April 2022, email IRB_123@medicine.zu.edu.eg.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.