ArticleHistochemistry and cell biology2025
Dysregulation of AR and ERα caused ovarian alterations in gerbils prenatally exposed to 17α-ethinylestradiol and pequi oil.
Article in Histochemistry and cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Prenatal monitoring in primary health care: a design science research-based approach to FHIR interoperability.Journal of biomedical semantics · 2026Article
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8 authors.
Funding
Abstract
This study investigated the effects of prenatal exposure to pequi oil and 17α-ethinylestradiol (EE2) on the histomorphometry and receptor expression (androgen receptor (AR) and estrogen receptor alpha (ERα) in gerbil ovaries (Meriones unguiculatus) during aging. Experimental groups included: control, vehicle (mineral oil), EE2: 15 µg/kg/day from gestational days 18-22, EE2/Pe: EE2 from days 18-22 and 300 mg/kg of pequi oil from days 18-26, and Pe: pequi oil only, via gavage. Female offspring were euthanized at 12 months, and ovaries were collected, processed histologically, and sectioned. Histological sections were stained with hematoxylin-eosin to analyze the superficial epithelium height and the tunica albuginea thickness. Immunohistochemistry for AR and ERα was performed, and the percentage of positive nuclei for these receptors was quantified in the theca interna, granulosa cells within follicles, and the interstitial gland. Data were analyzed using analysis of variance (ANOVA), Tukey's, and Kruskal-Wallis tests. The data revealed a significant decrease (p < 0.05) in the thickness of the tunica albuginea in the EE2 group, whereas this thickness was increased in the EE2/Pe and Pe groups. Epithelial height was lower in the EE2 group and higher in the EE2/Pe group. No significant changes in AR immunoreactivity were observed. In multilaminar follicles, ERα immunostaining was elevated in granulosa cells in the Pe group and in theca cells of the EE2 group. Additionally, the interstitial gland in the Pe group showed an increase in ERα expression. Pequi oil exposure upregulated ERα more markedly than AR during folliculogenesis and in interstitial cells, suggesting endocrine-modulating potential and relevance for ovarian regulation during aging.
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