ArticleMolecular biology reports2025
Association between SIRT-1 and SERPINA4 gene polymorphisms and the risk of idiopathic nephrotic syndrome among Egyptian children.
Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIdiopathic nephrotic syndrome (INS) is the primary cause of chronic glomerular dysfunction in children. Despite extensive research, its pathophysiology remains unclear, particularly in cases that are resistant to steroids.
aimThis research evaluated the impact of SIRT-1 (rs2273773) and SERPINA4 (rs2093266) gene variants on Egyptian children's susceptibility to INS and response to steroid therapy. METHODS AND
resultsGenetic polymorphisms of SIRT-1 (rs2273773) and SERPINA4 (rs2093266) were screened in 135 INS children and a similar number of healthy volunteers using real-time PCR. Concerning SIRT-1 rs2273773 genotypes, the cases showed markedly greater CT, TT genotypes, and T allele incidences than the reference group, which increased the risk of INS by 2.01-, 4.03-, and 1.88-folds, respectively. Regarding SERPINA4 rs2093266 genotypes, the cases exhibited notably higher GA, AA genotypes, and the A allele frequencies than controls, which enlarged the risk of INS by 3.1-, 5.47-, and 2.82-folds, respectively. The frequency of GA and AA genotypes and the presence of the A allele of SERPINA4 rs2093266 were considerably higher in steroid-resistant versus steroid-sensitive cases. The logistic regression model stated the serum creatinine, blood urea nitrogen, and the SERPINA4 rs2093266 polymorphism as independent contributors to the risk for steroid resistance in INS cases.
conclusionSIRT-1 (rs2273773) and SERPINA4 (rs2093266) gene polymorphisms significantly attributed to the risk of developing INS in Egyptian children. Furthermore, the SERPINA4 (rs2093266) polymorphism has a strong correlation with steroid resistance, suggesting that it could be a target for treatment to avoid severe renal problems and adverse steroid effects.
Indexed as
Identifiers
40402303What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.