ArticleNaunyn-Schmiedeberg's archives of pharmacology2025
Investigation of the protective effect of beta caryophyllene against indomethacin-induced gastric ulcer in rats: in vivo and in vitro study.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- β-caryophyllene attenuates lead acetate-induced hepatotoxicity through regulation of oxidative stress, inflammation, and PI3K/AKT/mTOR signaling.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Protective Effect of L-Arginine and Filgrastim Against Valproic Acid-Induced Histopathological Changes on the Gastric and Lingual Mucosa.Journal of applied toxicology : JAT · 2026Article
- β-caryophyllene protects against foodborne ochratoxin A-induced pancreatic toxicity: implications for food safety and environmental health.Molecular biology reports · 2026Article
- The synergistic protective effects of bioactive catechins in longjing tea: alleviate indomethacin-induced gastric toxicity through modulation of inflammatory and apoptotic pathways.Frontiers in pharmacology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
In this study, the protective and healing effects of beta-caryophyllene (BCP) on gastric mucosa in indomethacin (INDO)-induced gastric ulcer model were investigated. In the study, 116 male Sprague-Dawley rats were used. In in vivo experiments, rat was administered doses of 50-100-200 mg/kg BCP and 5 mg/kg omeprazole for 14 days, and indomethacin (100 mg/kg) was given on the last day. In in vitro experiments, the effects of BCP (250-500-1000 µg/ml) on gastric motility and acid secretion were examined by isolated organ bath method. It was found that INDO treatment increased MDA level in gastric tissue, but decreased GPx and SOD activities. Nrf2 and HO-1 levels were decreased in INDO-treated groups. INDO increased TNF-α, IL-1β, and NF-κB levels and iNOS activity, but decreased COX-1 activity and PGE2 levels. INDO induced ER stress and increased GRP78, ATF4, ATF6, p-IRE1, sXBP1, eIF2-α, and CHOP expression levels in gastric tissue. Bax, caspase-3, and caspase-12 levels increased in INDO group, while Bcl-2 level decreased. BCP showed protective activity in gastric tissue and brought these parameters closer to normal levels. In vitro studies revealed that BCP decreased ACh and KCl-induced gastric contractions. Again, BCP decreased gastric acid secretion via M3 receptor pathway but not via H2 and CCK2 receptor pathways. This study revealed that BCP showed healing effects by protecting gastric mucosa from oxidative stress, inflammation, ER stress, and apoptosis in INDO-induced gastric ulcer model. In addition, it was revealed that BCP affects gastric motility by regulating gastric acid secretion via M3 receptor pathway.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.