Evidence map›Paper›PMID 40402224›Full record

ArticlePediatric nephrology (Berlin, Germany)2025

Risk factors of acute kidney injury in extremely low gestational age neonates (ELGANs) - a retrospective case-control study.

Ling Li, Hui-Ling Shu, Shu-Dong Cui, Xiao-Lin Miao, Xiao-Qing Chen, Jing-Jing Pan, Yang Yang

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Article in Pediatric nephrology (Berlin, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Ling Li *Department of Neonatology, Jiangsu Province, The First Affiliated Hospital with Nanjing Medical University, Nanjing, P.R. China, 210000.
Hui-Ling Shu *Department of Neonatology, Jiangsu Province, Danyang Maternal and Child Health Hospital, Zhenjiang, P.R. China, 210000.
Shu-Dong CuiDepartment of Neonatology, Jiangsu Province, The First Affiliated Hospital with Nanjing Medical University, Nanjing, P.R. China, 210000.
Xiao-Lin MiaoDepartment of Neonatology, Jiangsu Province, The First Affiliated Hospital with Nanjing Medical University, Nanjing, P.R. China, 210000.
Xiao-Qing ChenDepartment of Neonatology, Jiangsu Province, The First Affiliated Hospital with Nanjing Medical University, Nanjing, P.R. China, 210000.
Jing-Jing PanDepartment of Neonatology, Jiangsu Province, The First Affiliated Hospital with Nanjing Medical University, Nanjing, P.R. China, 210000. pjj86961@163.com.
Yang YangDepartment of Neonatology, Jiangsu Province, Children's Hospital of Nanjing Medical University, Nanjing, P.R. China, 210008. yy860507@126.com.

Funding

Jiangsu Maternal and Child Health Association
6 · The paper itself

Abstract

backgroundNeonatal acute kidney injury (AKI) is associated with poor clinical outcomes. Consequently, this study was designed to explore the prenatal and postnatal risk factors in Chinese extremely low gestational age neonates (ELGANs).

methodsThis retrospective study included all ELGANs (born between 23-0/7 and 27-6/7 weeks of gestation) hospitalized from January 2019 to December 2022. These premature babies were divided into the AKI group (n = 39) and the non-AKI group (n = 76) according to the Kidney Disease: Improving Global Outcomes (KDIGO) criteria.

resultsAKI most frequently occurred in the first 10 days of life (median: 8th day, quartile range: 6th - 10th day). Most infants (61.54%) manifested stage 1 AKI. Lower gestational age (GA) was the major independent risk factor for AKI [adjusted OR (aOR): 0.40, 95% CI: 0.22-0.67]. Moreover, the lower the GA, the higher the risk of AKI. When the interactive effect between GA and nonsteroidal anti-inflammatory drugs (NSAIDs) was considered, NSAIDs administration would greatly enhance the risk of AKI (interaction term, aOR: 3.94, 95% CI: 1.26-13.92). The levels of serum creatinine and urea nitrogen in the AKI group generally returned to normal upon discharge and continued until 6 months after follow-up.

conclusionWhen using NSAIDs in the ELGANs population, great attention should be paid to dynamically monitor kidney function.

Indexed as

Acute Kidney InjuryAnti-Inflammatory Agents, Non-SteroidalInfant, Extremely PrematureInfant, Premature, DiseasesCase-Control StudiesChinaFemaleGestational AgeHumansInfant, NewbornMaleRetrospective StudiesRisk FactorsAnti-Inflammatory Agents, Non-SteroidalAcute kidney injuryExtremely low gestational age neonatesNon-steroidal anti-inflammatory drugsPremature infant

Identifiers

PMID40402224

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