Evidence map›Paper›PMID 40402081›Full record

ArticleAmerican journal of hypertension2025

Stenotic Lesions of the Intracranial Arteries in Relation to the Average Level and Variability of the Home Blood Pressure: A Cross-Sectional Study.

Dong-Yan Zhang, De-Wei An, Hui Chen, Jie Xu, Ying Wang, Yi-Bang Cheng, Qian-Hui Guo, Ming-Xuan Li, Qi-Fang Huang, Jian-Feng Huang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of hypertension, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Dong-Yan ZhangDepartment of Cardiovascular Medicine, Shanghai Institute of Hypertension, Shanghai Key Laboratory of Hypertension, State Key Laboratory of Medical Genomics, National Research Centre for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0003-0551-971X
De-Wei AnDepartment of Cardiovascular Medicine, Shanghai Institute of Hypertension, Shanghai Key Laboratory of Hypertension, State Key Laboratory of Medical Genomics, National Research Centre for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Hui ChenDepartment of Cardiovascular Medicine, Shanghai Institute of Hypertension, Shanghai Key Laboratory of Hypertension, State Key Laboratory of Medical Genomics, National Research Centre for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jie XuDepartment of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ying WangDepartment of Cardiovascular Medicine, Shanghai Institute of Hypertension, Shanghai Key Laboratory of Hypertension, State Key Laboratory of Medical Genomics, National Research Centre for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yi-Bang ChengDepartment of Cardiovascular Medicine, Shanghai Institute of Hypertension, Shanghai Key Laboratory of Hypertension, State Key Laboratory of Medical Genomics, National Research Centre for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Qian-Hui GuoDepartment of Cardiovascular Medicine, Shanghai Institute of Hypertension, Shanghai Key Laboratory of Hypertension, State Key Laboratory of Medical Genomics, National Research Centre for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ming-Xuan LiDepartment of Cardiovascular Medicine, Shanghai Institute of Hypertension, Shanghai Key Laboratory of Hypertension, State Key Laboratory of Medical Genomics, National Research Centre for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Qi-Fang HuangDepartment of Cardiovascular Medicine, Shanghai Institute of Hypertension, Shanghai Key Laboratory of Hypertension, State Key Laboratory of Medical Genomics, National Research Centre for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jian-Feng HuangDepartment of Cardiovascular Medicine, Shanghai Institute of Hypertension, Shanghai Key Laboratory of Hypertension, State Key Laboratory of Medical Genomics, National Research Centre for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chang-Sheng ShengDepartment of Cardiovascular Medicine, Shanghai Institute of Hypertension, Shanghai Key Laboratory of Hypertension, State Key Laboratory of Medical Genomics, National Research Centre for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ji-Guang WangDepartment of Cardiovascular Medicine, Shanghai Institute of Hypertension, Shanghai Key Laboratory of Hypertension, State Key Laboratory of Medical Genomics, National Research Centre for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jan A StaessenDepartment of Cardiovascular Medicine, Shanghai Institute of Hypertension, Shanghai Key Laboratory of Hypertension, State Key Laboratory of Medical Genomics, National Research Centre for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yan LiDepartment of Cardiovascular Medicine, Shanghai Institute of Hypertension, Shanghai Key Laboratory of Hypertension, State Key Laboratory of Medical Genomics, National Research Centre for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0002-5825-5968

Funding

APPREMEDNational Natural Science Foundation of China 82100445Natural Science Foundation of Shanghai 22ZR1452900
6 · The paper itself

Abstract

backgroundThis study assessed the presence of intracranial arterial stenosis (ICAS) in relation to home systolic blood pressure (SBP) and its variability (BPV).

methodsIn 1510 untreated patients, ICAS was assessed by transcranial Doppler ultrasonography. SBP and BPV were determined from individual home BP recordings over seven days with triplicate readings in the morning and evening. BP variability was expressed as standard deviation (SD), coefficient of variation (CV), variability independent of the mean (VIM), and average real variability (ARV). CV was SD divided by the mean, VIM was SD divided by the mean to the power x  and multiplied by the population mean to the power x, and ARV reflected the average absolute difference between consecutive BP readings. Associations with ICAS were assessed from nested multivariable logistic models.

resultsOne hundred and fourteen participants (7.5%) had ICAS. Combining all BP readings, SBP, SD, CV, VIM, and ARV averaged (± between-patient SD) 130.1 ± 11.9 mm Hg, 8.36 ± 2.53 mm Hg, 6.42 ± 1.83%, 8.36 ± 2.38, and 6.41 ± 1.61 mm Hg, respectively. In multivariable-adjusted models, higher home SBP was independently associated with increased prevalence of ICAS. For morning measurements, all variability indices were significantly associated with ICAS, with odds ratios per 1-SD increase ranging from 1.33 to 1.34 (P ≤ 0.005), independent of SBP level. In contrast, associations based on evening variability were non-significant. Sex and anatomical ICAS location did not impact these results.

conclusionsThe prevalence of ICAS was positively associated with SBP level. In addition to the SBP level, all four morning BPV indexes refined the assessment of ICAS prevalence.

Indexed as

Blood PressureBlood Pressure Monitoring, AmbulatoryAdultAgedCircadian RhythmConstriction, PathologicCross-Sectional StudiesFemaleHumansMaleMiddle AgedPrevalenceRisk FactorsUltrasonography, Doppler, Transcranialblood pressure variabilityhome blood pressure monitoringhypertensionintracranial arterial stenosis

Identifiers

PMID40402081
PMCPMC12448609

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.