ArticleChemistry (Weinheim an der Bergstrasse, Germany)2025
Intramolecular PCET of α-Keto Acids: Synthesis of Trifluoromethyl Ketones via Ketyl Radicals.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Divergent Access to Fluorinated Pharmacons From Ethyl Trifluoropyruvate.Advanced synthesis & catalysis · 2026Article
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Authors and funding
5 authors.
Funding
Abstract
Due to favourable pharmacological properties, the introduction of the fluorine atom into small molecules has become increasingly more common over the past few decades. In particular, the trifluoromethyl ketone group is of great interest due to its role as a carboxylic acid bioisostere. Recently, these fragments have been accessed via acyl radical equivalents. Herein, we disclose an unconventional intramolecular proton-coupled electron transfer activation of α-keto acids by photoredox catalysis to generate ketyl radicals toward accessing functionalizable lactones. These lactones serve as synthons for modular one-pot syntheses of trifluoromethyl ketones in a net dicarbofunctionalization of electron-rich olefins.
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Registered trials
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