Evidence map›Paper›PMID 40402002›Full record

ArticleEuropean journal of heart failure2025

Renal denervation improves cardiac function and exercise duration in a miniswine model of heart failure with preserved ejection fraction.

David J Lefer, Thomas E Sharp, Amy L Scarborough, Amelia G Haydel, Sanjiv J Shah, Zhen Li, Traci T Goodchild

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of heart failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Renal Denervation in Cardiovascular Diseases: Mechanisms, Evidence, and Expanding Applications.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026
    Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

David J LeferDepartment of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Thomas E SharpDepartment of Molecular Pharmacology and Physiology, Heart Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Amy L ScarboroughCardiovascular Center of Excellence, Louisiana State University Health Science Center, New Orleans, LA, USA.
Amelia G HaydelCardiovascular Center of Excellence, Louisiana State University Health Science Center, New Orleans, LA, USA.
Sanjiv J ShahNorthwestern University Feinberg School of Medicine, Chicago, IL, USA.
Zhen LiDepartment of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Traci T GoodchildDepartment of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Funding

Roles of Endothelial and Smooth Muscle KATP Channels in Myocardial Ischemic InjuryR01HL146514 · NHLBI · LSU HEALTH SCIENCES CENTER · PI COETZEE, WILLIAM A, LEFER, DAVID JOSEPH · 2020 to 2023
$3.0M
Renal Denervation in Heart Failure with Preserved Ejection FractionR01HL159428 · NHLBI · LSU HEALTH SCIENCES CENTER · PI GOODCHILD, TRACI TAYLOR · 2021 to 2024
$2.9M
Hydrogen Sulfide Regulation in CardioprotectionR01HL151398 · NHLBI · BROWN UNIVERSITY · PI LEFER, DAVID JOSEPH, XIAN, MING · 2020 to 2023
$2.3M
Alcohol-induced Gut Dysbiosis and Cardiovascular DiseaseR01AA029984 · NIAAA · UNIVERSITY OF SOUTH FLORIDA · PI Thomas E. Sharp · 2022 to 2026
$2.1M
Endogenous Hydrogen Sulfide Enzymes in Heart FailureR01HL146098 · NHLBI · LSU HEALTH SCIENCES CENTER · PI XIA, HUIJING · 2019 to 2022
$1.6M
Hydrogen Sulfide and GLP-1 Combination Therapy to Treat HFpEFR01HL181016 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI DAVID JOSEPH LEFER · 2025 to 2026
$1.5M
National Institutes of Health (NIH) AA029984National Institutes of Health (NIH) HL146098National Institutes of Health (NIH) HL146514National Institutes of Health (NIH) HL151398National Institutes of Health (NIH) HL159428NHLBI NIH HHS R01 HL146098NHLBI NIH HHS R01 HL146514NHLBI NIH HHS R01 HL151398NHLBI NIH HHS R01 HL159428NHLBI NIH HHS R01 HL181016NIAAA NIH HHS R01 AA029984
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID40402002
PMCPMC12575413

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.