Evidence map›Paper›PMID 40401967›Full record

ArticleMicrobiology spectrum2025

"Acceptable" concentrations of enrofloxacin in food lead to reduced enrofloxacin susceptibility in a mouse model of gastrointestinal

Zina Gestels, Bianca Torfs, Said Abdellati, Irith De Baetselier, Caroline Rombouts, Veronique Dermauw, Sheeba Santhini Manoharan-Basil, Chris Kenyon

Abstract read
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In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zina GestelsSTI Unit, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Flanders, Belgium.ORCID 0000-0001-8790-3517
Bianca TorfsApplied Technology and Production unit, Institute of Tropical Medicine, Antwerp, Flanders, Belgium.
Said AbdellatiClinical and Reference Laboratory, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Flanders, Belgium.
Irith De BaetselierClinical and Reference Laboratory, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Flanders, Belgium.ORCID 0000-0002-1804-252X
Caroline RomboutsApplied Technology and Production unit, Institute of Tropical Medicine, Antwerp, Flanders, Belgium.
Veronique Dermauw *Unit of Zoonoses, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Flanders, Belgium.
Sheeba Santhini Manoharan-Basil *STI Unit, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Flanders, Belgium.ORCID 0000-0001-8421-5137
Chris Kenyon *STI Unit, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Flanders, Belgium.ORCID 0000-0002-2557-8998

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Concentrations of antimicrobials up to 1,000-fold lower than the minimum inhibitory concentration can select for antimicrobial resistance. This generates the hypothesis that the low concentrations of antimicrobials allowed in our food could select for resistance. We assessed if the dose of enrofloxacin allowed in food by the European Medicines Agency (6.2 µg/kg) could decrease susceptibility to enrofloxacin in a strain of

Indexed as

Anti-Bacterial AgentsEnrofloxacinFluoroquinolonesGastrointestinal TractKlebsiella InfectionsKlebsiella pneumoniaeAnimalsDisease Models, AnimalDrug Resistance, BacterialFemaleHumansMiceMicrobial Sensitivity TestsSpecific Pathogen-Free OrganismsAnti-Bacterial AgentsEnrofloxacinFluoroquinolonesacceptable daily intakeADIantimicrobial resistanceenrofloxacinKlebsiella pneumoniaeminimum selection concentration

Identifiers

PMID40401967
PMCPMC12210917

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.