Evidence map›Paper›PMID 40401943›Full record

ArticleMicrobiology resource announcements2025

RefAHL: a curated quorum sensing reference linking diverse LuxI-type signal synthases with their acyl-homoserine lactone products.

Amy L Schaefer, Ethan G Murdock, Dale A Pelletier, Caroline S Harwood, E Peter Greenberg, Aaron W Puri

Erratum issuedAbstract read
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In one paragraph

Article in Microbiology resource announcements, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. MrtR ofProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Amy L SchaeferDepartment of Microbiology, University of Washington, Seattle, Washington, USA.ORCID 0000-0003-0581-054X
Ethan G MurdockDepartment of Chemistry, Henry Eyring Center for Cell and Genome Science, University of Utah, Salt Lake City, Utah, USA.ORCID 0000-0002-2624-5394
Dale A PelletierBiosciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA.ORCID 0000-0002-4321-7918
Caroline S HarwoodDepartment of Microbiology, University of Washington, Seattle, Washington, USA.ORCID 0000-0003-4450-5177
E Peter GreenbergDepartment of Microbiology, University of Washington, Seattle, Washington, USA.ORCID 0000-0001-9474-8041
Aaron W PuriDepartment of Chemistry, Henry Eyring Center for Cell and Genome Science, University of Utah, Salt Lake City, Utah, USA.ORCID 0000-0002-6378-678X

Funding

Quorum sensing in Pseudomonas aeruginosa - Equipment SupplementR35GM136218 · NIGMS · UNIVERSITY OF WASHINGTON · PI Everett P Greenberg · 2020 to 2026
$2.9M
Methylotrophs: underexplored bacteria for discovering novel natural products and biochemistryR35GM147018 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Aaron Webster Puri · 2022 to 2026
$1.9M
Methane-oxidizing bacterial communities: A novel source of bioactive chemical diversityR00GM118762 · NIGMS · UNIVERSITY OF UTAH · PI PURI, AARON WEBSTER · 2019 to 2021
$743k
Methane-Oxidizing Bacterial Communities: A Novel Source Of Bioactive Chemical DiversityK99GM118762 · NIGMS · UNIVERSITY OF WASHINGTON · PI PURI, AARON WEBSTER · 2016 to 2017
$161k
National Science Foundation 2339190NIGMS NIH HHS K99 GM118762NIGMS NIH HHS R00 GM118762NIGMS NIH HHS R35 GM118762NIGMS NIH HHS R35 GM136218NIGMS NIH HHS R35 GM147018U.S. Department of Energy DE-AC05-00OR22725
6 · The paper itself

Abstract

Some bacteria use acyl-homoserine lactone (AHL) signals in quorum sensing, a type of cell-cell communication. Here, we present "RefAHL," an updated, curated collection of LuxI-type AHL synthases with their AHL products and associated metadata. RefAHL is publicly available as a community resource to help catalog LuxI-type diversity encoded in (meta) genomic data.

Indexed as

acyl-homoserine lactoneAHLquorum sensingsociomicrobiology

Identifiers

PMID40401943
PMCPMC12160550

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.