Evidence map›Paper›PMID 40401902›Full record

ArticlemSphere2025

Comparative pathogenicity of three A(H5N1) clade 2.3.4.4b HPAI viruses in blue-winged teal and transmission to domestic poultry.

Tamiru N Alkie, Carissa Embury-Hyatt, Anthony V Signore, Frank Baldwin, Tamiko Hisanaga, Wanhong Xu, Estella Moffat, Jolene A Giacinti, Catherine Soos, Yohannes Berhane

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tamiru N AlkieCanadian Food Inspection Agency, National Centre for Foreign Animal Disease, Winnipeg, Manitoba, Canada.
Carissa Embury-HyattCanadian Food Inspection Agency, National Centre for Foreign Animal Disease, Winnipeg, Manitoba, Canada.
Anthony V SignoreCanadian Food Inspection Agency, National Centre for Foreign Animal Disease, Winnipeg, Manitoba, Canada.
Frank BaldwinPrairie Region Wildlife and Habitat Assessment Section, Canadian Wildlife Service, Environment and Climate Change Canada, Delta, British Columbia, Canada.
Tamiko HisanagaCanadian Food Inspection Agency, National Centre for Foreign Animal Disease, Winnipeg, Manitoba, Canada.
Wanhong XuCanadian Food Inspection Agency, National Centre for Foreign Animal Disease, Winnipeg, Manitoba, Canada.
Estella MoffatCanadian Food Inspection Agency, National Centre for Foreign Animal Disease, Winnipeg, Manitoba, Canada.
Jolene A GiacintiEcotoxicology and Wildlife Health Division, Environment and Climate Change Canada, Government of Canada, Ottawa, Ontario, Canada.ORCID 0000-0002-4843-599X
Catherine SoosEcotoxicology & Wildlife Health Division, Science and Technology Branch, Ecotoxicology & Wildlife Health Division, Government of Canada, Ottawa, Ontario, Canada.
Yohannes BerhaneCanadian Food Inspection Agency, National Centre for Foreign Animal Disease, Winnipeg, Manitoba, Canada.ORCID 0000-0002-5958-3525

Funding

Canadian Safety and Security Program CSSP-2024-TI-2673
6 · The paper itself

Abstract

Long-distance migratory ducks play a critical role in the maintenance and dissemination of A(H5N1) viruses. Comparative pathogenicity studies were conducted on blue-winged teal (BWTE; IMPORTANCE: The recurrent incursions of A(H5N1) clade 2.3.4.4b viruses into North America have resulted in the emergence of reassortant virus genotypes. These genotypes exhibit variations in pathogenicity and host ranges. Blue-winged teal (BWTE) are the most common dabbling ducks in North America and play a crucial role in maintaining and dispersing influenza A viruses (IAVs). In some areas, the migratory pathways of BWTE overlap with densely populated commercial poultry facilities. Despite this, the role of BWTE in the maintenance and spread of A(H5N1) is not well understood, and there is limited data on their susceptibility to A(H5N1) clade 2.3.4.4b viruses. Our study demonstrates differences in BWTE susceptibility to distinct genotypes of A(H5N1) clade 2.3.4.4b viruses. The virus transmission from infected BWTE and lethality in turkeys and chickens were also influenced by the virus genotypes. The findings suggest that BWTE could contribute to the maintenance and spread of highly pathogenic avian influenza (HPAI) viruses, and active surveillance in BWTE is essential.

Indexed as

DucksInfluenza A Virus, H5N1 SubtypeInfluenza in BirdsPoultry DiseasesAnimalsCanadaChickensGenotypeReassortant VirusesTurkeysVirulenceVirus SheddingA(H5N1)clade 2.3.4.4bduckspathogenicitypoultrytransmission

Identifiers

PMID40401902
PMCPMC12188715

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.