ArticleDermatology practical & conceptual2025
Melanoma on Chronically Sun-Damaged Skin: Deciphering Gene Expression Signatures.
Article in Dermatology practical & conceptual, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- Ultraviolet radiation as a double-edged regulator of melanocyte function in vitiligo therapy and melanoma carcinogenesis.Frontiers in medicine · 2026Review
- Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMelanoma of the skin is responsible for most skin cancer-related deaths. It is well known that exposure to ultraviolet radiation is the most common and modifiable risk factor for melanoma. Melanomas arising on chronically sun-damaged skin (CSDS) have shown a higher mutational burden.
objectivesTo analyze skin samples of patients with melanoma on CSDS to identify possible gene expression signatures that may contribute to melanomagenesis.
methodsThis experimental observational analysis, conducted at the Dermatology Melanoma and Pigmented Lesion Clinic at University of Miami Hospitals/Sylvester Comprehensive Cancer Center, Miami, Florida, included a total of 10 patients over 18 years of age with a recent diagnosis of melanoma on CSDS. For each patient, two skin samples were obtained using a 2-mm punch (one from CSDS within 2 cm of the primary melanoma, another from sun-protected skin). Skin samples were sent to the Sylvester Onco-genomics Shared Resource (OGSR) for library preparation and RNA sequencing. Main outcome was the identification of differentially expressed genes between CSDS and non-CSDS of patients with a recent diagnosis of melanoma.
resultsA total of four skin samples met the necessary quality standards for molecular analyses. Significant differences were observed between the CSDS and non-CSDS samples. Pathways involved in inflammation (e.g., IL-17 signaling), immune responses (e.g., ABC transporters), and oxidative phosphorylation were overexpressed in CSDS.
conclusionsCSDS can be an adequate milieu for the development and progression of melanoma. CSDS reveals overexpression of pathways involved in inflammation, immune responses, and oxidative phosphorylation, all of which may facilitate interactions between the skin microenvironment and melanocytes/melanoma cells, predisposing to melanoma development and progression.
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Registered trials
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