Evidence map›Paper›PMID 40401807›Full record

ArticleChemical research in toxicology2025

Short-Term and Long-Term Effects of Electronic Cigarettes on Mouse Lungs Following Nose-Only Exposures.

Indu Sinha, Zachary Bitzer, Stephanie Barnett, Lisa Reinhart, Todd M Umstead, Zissis C Chroneos, Matthew Lanza, Dongxiao Sun, Junjia Zhu, John P Richie and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical research in toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Indu SinhaDepartment of Molecular and Precision Medicine, Penn State College of Medicine, Hershey, Pennsylvania 17033, United States.
Zachary BitzerDepartment of Public Health Sciences, Penn State College of Medicine, Hershey, Pennsylvania 17033, United States.
Stephanie BarnettDepartment of Public Health Sciences, Penn State College of Medicine, Hershey, Pennsylvania 17033, United States.
Lisa ReinhartDepartment of Public Health Sciences, Penn State College of Medicine, Hershey, Pennsylvania 17033, United States.ORCID 0000-0001-6266-3342
Todd M UmsteadDepartment of Pediatrics, Penn State College of Medicine, Hershey, Pennsylvania 17033, United States.
Zissis C ChroneosDepartment of Pediatrics, Penn State College of Medicine, Hershey, Pennsylvania 17033, United States.ORCID 0000-0002-9841-7917
Matthew LanzaDepartment of Comparative Medicine, Penn State College of Medicine, Hershey, Pennsylvania 17033, United States.
Dongxiao SunMass Spectrometry Core Facility (small molecule), Department of Pharmacology, Penn State College of Medicine, Hershey, Pennsylvania 17033, United States.
Junjia ZhuDepartment of Public Health Sciences, Penn State College of Medicine, Hershey, Pennsylvania 17033, United States.
John P RichieDepartment of Public Health Sciences, Penn State College of Medicine, Hershey, Pennsylvania 17033, United States.
Raghu SinhaDepartment of Molecular and Precision Medicine, Penn State College of Medicine, Hershey, Pennsylvania 17033, United States.ORCID 0000-0001-9083-8533

Funding

Translational Studies on Electronic Cigarette-derived Oxidants and their Long-term Pulmonary EffectsR01HL152436 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SINHA, RAGHU · 2020 to 2022
$1.4M
NHLBI NIH HHS R01 HL152436
6 · The paper itself

Abstract

Health effects of electronic cigarettes (ECs) remain unknown, despite their popularity. We have determined that ECs produce highly reactive free radicals that could potentially cause damage in exposed tissues, mainly lungs. Goal for this study was to investigate the short- and long-term effects of ECs in mouse lungs. We focused on evaluating lung functions, oxidative stress related markers, and lung injury following nose-only exposures in male and female mice after 4- and 12-week periods. The EC exposure was modeled

Indexed as

Electronic Nicotine Delivery SystemsLungAerosolsAnimalsBiomarkersFemaleMaleMiceMice, Inbred C57BLOxidative StressAerosolsBiomarkers

Identifiers

PMID40401807
PMCPMC12175837

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.