Evidence map›Paper›PMID 40401784›Full record

Trial reportNeurorehabilitation and neural repair2025

Task Practice With and Without Aerobic Exercise Improves Health-related Quality of Life and Social Participation Post-stroke: A Randomized Clinical Trial.

Susan M Linder, Andrea Bischof-Bockbrader, Ozlenen Eylul Ince Hocaoglu, Francois Bethoux, Sara Davidson, Donayja Harris, Yadi Li, Brittany Lapin, Jay L Alberts

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neurorehabilitation and neural repair, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Susan M LinderCleveland Clinic, Department of Physical Medicine and Rehabilitation, Cleveland, OH, USA.ORCID 0000-0002-9094-9740
Andrea Bischof-BockbraderCleveland Clinic, Department of Physical Medicine and Rehabilitation, Cleveland, OH, USA.
Ozlenen Eylul Ince HocaogluCleveland Clinic, Department of Physical Medicine and Rehabilitation, Cleveland, OH, USA.ORCID 0009-0007-2734-4849
Francois BethouxCleveland Clinic, Department of Physical Medicine and Rehabilitation, Cleveland, OH, USA.
Sara DavidsonCleveland Clinic, Concussion Center, Neurologic Institute, Cleveland, OH, USA.
Donayja HarrisCleveland Clinic, Department of Physical Medicine and Rehabilitation, Cleveland, OH, USA.
Yadi LiCleveland Clinic, Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland, OH, USA.ORCID 0000-0003-4930-2168
Brittany LapinCleveland Clinic, Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland, OH, USA.
Jay L AlbertsCleveland Clinic, Department of Biomedical Engineering, Lerner Research Institute, Cleveland, OH, USA.

Funding

Cost-effectiveness and efficacy of a combined intervention to facilitate motor recovery following strokeK01HD092556 · NICHD · CLEVELAND CLINIC LERNER COM-CWRU · PI LINDER, SUSAN MARIE · 2018 to 2022
$666k
NICHD NIH HHS K01 HD092556
6 · The paper itself

Abstract

backgroundPhysical, cognitive, and psychosocial impairments experienced by individuals post-stroke detrimentally impact health-related quality of life (HRQoL). Rehabilitation interventions targeting the recovery of motor function aim to improve community reintegration and HRQoL. Aerobic exercise has also been shown to have global effects in individuals post-stroke, positively affecting motor and mood-related outcomes.

objectiveTo determine the effects of forced-rate aerobic exercise (FE) coupled with upper extremity repetitive task practice (RTP) on HRQoL and mood in individuals post-stroke.

methodsA rater blinded randomized clinical trial was conducted. Individuals ≥6 months post-stroke received 90-minute sessions of FE+RTP or time-matched RTP alone, 3×/week for 8 weeks. The Stroke Impact Scale (SIS), Patient-Reported Outcomes Measurement Information System (PROMIS-29), and Centers For Epidemiology Studies-Depression Scale (CES-D) were administered at baseline, end of treatment (EOT), EOT+6 months, and EOT+12 months.

resultsSixty participants enrolled in the study and 57 completed the self-reported questionnaires (FE + RTP, N = 29; RTP alone, N = 28). Both groups improved significantly at each time point in the following SIS domains: physical problems, feelings, activities of daily living, mobility, hand use, meaningful activities, and overall recovery; and in the participation domain of PROMIS-29. Depressive symptomology as measured by CES-D improved from baseline to EOT+6. There were no significant group differences in any of the outcomes.

conclusionsBoth interventions were comparably effective in improving HRQoL despite the FE+RTP group receiving only half the dose of RTP compared to the control group (RTP only). Improvements were maintained up to 1 year post-intervention.

Indexed as

ExerciseExercise TherapyQuality of LifeSocial ParticipationStrokeStroke RehabilitationAgedFemaleHumansMaleMiddle AgedPatient Reported Outcome MeasuresSingle-Blind MethodUpper Extremitycyclingdepressionrepetitive task practicestroke rehabilitation

Identifiers

PMID40401784
PMCPMC12324965

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.