Evidence map›Paper›PMID 40401776›Full record

GuidelineEuropean stroke journal2025

European Stroke Organisation (ESO) guideline on aphasia rehabilitation.

Marian C Brady, Claire Mills, Hege Prag Øra, Natalia Novaes, Frank Becker, Fofi Constantinidou, Agnes Flöel, Katharina S Sunnerhagen, Jytte Isaksen, Caroline Jagoe and 8 more

Abstract readPractice Guideline
In one paragraph

Guideline in European stroke journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Acute-Phase Machine Learning Prediction of 12-Month Aphasia and Discourse Recovery.medRxiv : the preprint server for health sciences · 2026
    Article
  5. Review
  6. Article
  7. The nonlinear trajectory of post-stroke aphasia recovery.Frontiers in human neuroscience · 2026
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Editorial.European stroke journal · 2025
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Marian C BradyGlasgow Caledonian University, Glasgow, UK.ORCID 0000-0002-4589-7021
Claire MillsLeeds Teaching Hospitals NHS Trust, Leeds, UK.ORCID 0000-0002-3436-3876
Hege Prag ØraSunnaas Rehabilitation Hospital, Bjørnemyr, Norway.ORCID 0000-0002-8398-0651
Natalia NovaesHôpital Sainte Anne, Paris, France.
Frank BeckerSunnaas Rehabilitation Hospital, Bjørnemyr, Norway.ORCID 0000-0002-0857-0628
Fofi ConstantinidouDepartment of Psychology & Center for Applied Neuroscience, University of Cyprus, Nicosia, Cyprus.ORCID 0000-0002-7928-8363
Agnes FlöelDepartment of Neurology, University Medicine Greifswald, Greifswald, Germany.ORCID 0000-0002-1475-5872
Katharina S SunnerhagenInstitute of Neuroscience, Sahlgrenska University Hospital, Göteborg, Sweden.ORCID 0000-0002-5940-4400
Jytte IsaksenNeurorehabilitation Research and Knowledge Centre, Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0002-2502-029X
Caroline JagoeDepartment of Clinical Speech & Language Studies, Trinity College, The University of Dublin, Dublin, Ireland.ORCID 0000-0002-3015-1550
Luis Mt JesusUniversidade de Aveiro, Aveiro, Portugal.ORCID 0000-0002-8534-3218
Paola MarangoloDepartment of Humanities Studies, University Federico II, Naples, Italy.ORCID 0000-0002-1516-9832
Marcus MeinzerDepartment of Neurology, University Medicine Greifswald, Greifswald, Germany.ORCID 0000-0003-1370-3947
Ineke van der MeulenErasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID 0000-0002-6156-3873
Pauline CampbellGlasgow Caledonian University, Glasgow, UK.ORCID 0000-0002-5879-5526
Leonard HoAdvanced Care Research Centre, University of Edinburgh, Edinburgh, UK.ORCID 0000-0001-8353-9631
Salman HussainEuropean Stroke Organisation, Basel, Switzerland.ORCID 0000-0002-1691-8428
Katerina HilariCentre for Language and Communication Science Research, City St George's, University of London, London, UK.ORCID 0000-0003-2091-4849

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Evidence of effective aphasia rehabilitation is emerging, yet intervention and delivery varies widely. This European Stroke Organisation guideline adhered to the guideline development standard procedures and Grading of Recommendations, Assessment, Development and Evaluation (GRADE) methodology. The resulting multi-disciplinary, evidence-based recommendations support the delivery of high-quality stroke-related aphasia rehabilitation. The working group identified 10 clinically relevant aphasia rehabilitation questions and rated outcomes' relevance and importance. Following systematic searching, independent reviewers screened title-abstracts and full-texts for randomised controlled trials of speech-language therapy (SLT) for stroke-related aphasia. Results were profiled using PRISMA. Risk-of-bias was evaluated using the Cochrane Risk-of-Bias 1 tool. We prioritised final-value data. Where possible we conducted meta-analyses (RevMan) using random effects and mean, standardised mean differences (functional communication, quality of life, aphasia severity, auditory comprehension and spoken language outcomes) or odds ratios (adverse events). Using GRADE, we judged quality of the evidence (high-to-very low) and ESO recommendation strength (very strong-to-very weak). Where evidence was insufficient to support recommendations, expert opinions were described. Based on low-quality evidence we recommend the provision of higher total SLT dose (⩾20 h) and suggest higher SLT intensity and frequency to improve outcomes in aphasia rehabilitation. Similarly, we suggest the provision of individually-tailored SLT and digital and group therapy delivery models. Very low-level evidence for transcranial direct current stimulation (tDCS) with SLT informed the expert consensus that such interventions should only be provided in the context of high-quality trials. Evidence-based clinical-research priorities to inform SLT aphasia rehabilitation intervention choice and delivery are highlighted.

Indexed as

AphasiaSpeech TherapyStrokeStroke RehabilitationEuropeHumansLanguage Therapyaphasiabrain stimulationGuidelinemeta-analysisspeech and language therapystrokesystematic review

Identifiers

PMID40401776
PMCPMC12098336

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.