Evidence map›Paper›PMID 40401713›Full record

ArticleEpigenetics2025

PRMT1 promotes immune escape in hepatocellular carcinoma by regulating arginine methylation modification of MYC protein.

Han Zhou, Yang Wang, Dan Wang, Mei Zhang, Kaidi Wang, Chunhui Liu

Abstract read
In one paragraph

Article in Epigenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Han ZhouGeneral Surgery Department, North China University of Science and Technology Affiliated Hospital, Tangshan, Hebei, China.
Yang WangGastrointestinal Surgery Department, Tangshan Central Hospital, Tangshan, Hebei, China.
Dan WangAnesthesiology Department, Nanjing Chest Hospital, Nanjing, Jiangsu, China.
Mei ZhangGeneral Surgery Department. II, Tangshan Nanhu Hospital, Tangshan, Hebei, China.
Kaidi WangGeriatrics Department, North China University of Science and Technology Affiliated Hospital, Tangshan, Hebei, China.
Chunhui LiuGeneral Surgery Department, North China University of Science and Technology Affiliated Hospital, Tangshan, Hebei, China.ORCID 0009-0009-6484-8725

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Arginine methyltransferase 1 (PRMT1) is widely recognized as an oncogene in various cancers. However, its specific role and underlying mechanisms in hepatocellular carcinoma (HCC) remain insufficiently understood. This study investigated the function of PRMT1 in HCC development and immune evasion. A comprehensive approach combining database analysis (including TCGA, The Human Protein Atlas, Kaplan-Meier Plotter, and TIMER2.0), molecular techniques (such as RT-qPCR, Western blot analysis, and co-immunoprecipitation), cell-based assays (including MTT, colony formation, transwell, and T cell killing assays), and

Indexed as

ArginineCarcinoma, HepatocellularLiver NeoplasmsProtein-Arginine N-MethyltransferasesProto-Oncogene Proteins c-mycRepressor ProteinsAnimalsCell Line, TumorCell MovementCell ProliferationGene Expression Regulation, NeoplasticHumansImmune EvasionMethylationMiceTumor EscapeArginineMYC protein, humanPRMT1 protein, humanProtein-Arginine N-MethyltransferasesProto-Oncogene Proteins c-mycRepressor ProteinsArginine methylationhepatocellular carcinomaimmune escapeMYCPRMT1

Identifiers

PMID40401713
PMCPMC12101584

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.