Evidence map›Paper›PMID 40401624›Full record

ArticleJournal of the American Heart Association2025

Temperature Exposure and Acute Cardiovascular Disease Risk in New York City: Case Time Series.

Helena Krasnov, Kiran P Nagdeo, Pablo Knobel, Elena Colicino, Allan Just, Michael Hadley, Maayan Yitshak-Sade

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Helena KrasnovDepartment of Environmental Medicine Icahn School of Medicine at Mount Sinai New York NY USA.ORCID 0000-0003-0230-3112
Kiran P NagdeoDepartment of Environmental Medicine Icahn School of Medicine at Mount Sinai New York NY USA.
Pablo KnobelDepartment of Environmental Medicine Icahn School of Medicine at Mount Sinai New York NY USA.ORCID 0000-0001-6902-0286
Elena ColicinoDepartment of Environmental Medicine Icahn School of Medicine at Mount Sinai New York NY USA.ORCID 0000-0002-1875-8448
Allan JustDepartment of Epidemiology Brown University School of Public Health Providence RI USA.
Michael HadleyDepartment of Environmental Medicine Icahn School of Medicine at Mount Sinai New York NY USA.ORCID 0000-0002-3794-7877
Maayan Yitshak-SadeDepartment of Environmental Medicine Icahn School of Medicine at Mount Sinai New York NY USA.ORCID 0000-0003-4453-0401

Funding

Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
The Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Manish Arora · 2014 to 2026
$21.3M
Early-life metal exposures, mitochondrial heteroplasmy, and child antibody response to vaccinationR01ES034521 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Elena Colicino, Todd Jusko · 2022 to 2026
$3.0M
NCATS NIH HHS UL1 TR004419NIEHS NIH HHS P30 ES023515NIEHS NIH HHS R01 ES034521
6 · The paper itself

Abstract

backgroundNumerous studies investigated the associations between myocardial infarction (MI), ischemic stroke, and temperature exposure, but the results vary widely, particularly in dense metropolitan areas.

methodsWe included all patients admitted to Mount Sinai hospitals with MI or ischemic stroke (2011-2019). We obtained daily mean, minimal, maximal, and diurnal temperature range (DTR) exposures from geospatial models. We used distributed lag nonlinear models in a case time series design to study the cumulative associations of each outcome with exposure to the different temperature metrics at lag days 0 to 6.

resultsWe included 8933 individuals. We found cumulative higher odds of ischemic stroke associated with higher mean (odds ratio [OR], 1.010 [95% CI, 1.004-1.016]); maximal (OR, 1.010 [95% CI, 1.004-1.015]) and minimal temperatures (OR, 1.011 [95% CI, 1.004-1.017]) on 0 to 6 days before the event. We observed a nonlinear association between DTR and MI. Comparing exposure at the 10th percentile of DTR (3.8 °C) to the median (8 °C), we observed an OR of 1.332 (95% CI, 1.164-1.528), with similar effect estimates across lags. The OR of MI among those exposed to 12 °C (the 90th percentile of DTR) compared with the median was 1.041 (95% CI, 0.932-1.163).

conclusionsWe found higher odds of ischemic stroke associated with increased temperature exposures, highlighting the potential stroke risks in a warming climate. Additionally, we found higher odds of MI associated with lower DTR, a pattern more common on colder days. This suggests DTR may capture cardiac effects not observed using traditional exposure metrics.

Indexed as

Hot TemperatureIschemic StrokeMyocardial InfarctionTemperatureAgedFemaleHumansMaleMiddle AgedNew York CityRetrospective StudiesRisk AssessmentRisk FactorsTime Factorsdiurnal temperature rangemyocardial infarctionstroketemperaturecardiovascular disease

Identifiers

PMID40401624
PMCPMC12229218

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.