ArticleJournal of the American Heart Association2025
Two-Year Changes in Remnant Cholesterol and Stroke Risk in the Chinese Population: A Prospective Cohort Study.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Remnant Cholesterol and Atherosclerotic Cardiovascular Disease Risk in Populations With Different Low-Density Lipoprotein Cholesterol Elevations: A Prospective Cohort Study.Journal of the American Heart Association · 2026Article
- Residual cholesterol correlates with mild cognitive impairment, particularly for executive dysfunction among male individuals with type 2 diabetes mellitus.Frontiers in endocrinology · 2026Article
- Nonlinear association between remnant cholesterol inflammation index and incident stroke among middle-aged and older adults with hypertension: a CHARLS cohort study.Frontiers in cardiovascular medicine · 2026Article
- Impact of Remnant Cholesterol on the Risk for End-Stage Renal Disease in Type 2 Diabetes Mellitus: A Nationwide Population-Based Cohort Study (Diabetes Metab J 2025;49:1106-15).Diabetes & metabolism journal · 2026Article
- Association of remnant cholesterol and cholesterol, high-density lipoprotein, and glucose index with unfavorable outcomes after intravenous thrombolysis in acute ischemic stroke: a dual-center cohort study.Frontiers in immunology · 2026Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies have shown that elevated remnant cholesterol (RC) was associated with stroke risk. There is insufficient evidence on the relationship between 2-year changes in RC and stroke risk in the general population. Our aim was to explore the relationship between 2-year changes in RC and the risks of stroke and its subtypes in the general population.
methodsThe study included 62 443 individuals who were free of stroke from the Kailuan Study. Two-year changes in RC was defined as the difference between the RC in 2008 and that in 2006. Multivariable-adjusted Cox proportion models were used to examine the associations between 2-year changes in RC with the risks of stroke and its subtypes.
resultsDuring a median follow-up period of 10.30 years, 3780 (6.38%) stroke events occurred. The changes in RC were positively associated with the risk of stroke, after adjustment for multiple potential confounders. The hazard ratio (HR) for the Q4 group versus the Q1 group was 1.14 (95%, CI, 1.02-1.28) for stroke, and 1.18 (95% CI, 1.04-1.32) for ischemic stroke. The risks of stroke were higher in the RC increased group than the RC nonincreased group. The HR was 1.12 (95% CI, 1.04-1.20) for stroke, and 1.15 (95% CI, 1.07-1.24) for ischemic stroke.
conclusionsSubstantial changes in RC are associated with increased risks of stroke in the general population. Monitoring long-term changes in RC may assist with the early identification of individuals at high risk of stroke.
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